人体功能性光声无创多普勒血管造影术
Functional photoacoustic noninvasive Doppler angiography in humans
AI总结：
针对传统光学血流成像深度浅的问题，提出协同光声与多普勒效应的PANDA技术，将成像深度提升约一个数量级至1厘米，具备三维、便携式特点，已在健康人和静脉曲张患者中验证临床可行性。
摘要：
血流光学成像可为循环系统提供关键的功能学洞察，但由于生物组织中的光散射，其临床应用通常局限于浅层深度（约1毫米）。本文中，我们提出用于深部血流成像的光声无创多普勒血管造影术（photoacoustic noninvasive Doppler angiography, PANDA）。PANDA协同利用光声效应与多普勒效应，生成血管腔的彩色多普勒流速图与能量多普勒血流图。我们的结果表明，PANDA能够在体内测量深达1厘米的血流，较现有的高分辨率纯光学模态提升了约一个数量级。PANDA通过增加成像深度、实现血管横截面成像，改进了光声血流成像技术。我们还通过对健康受试者及一名静脉曲张患者的血流进行三维成像，展示了PANDA的临床可行性。通过将成像系统集成到移动平台上，我们将PANDA设计为一种便携式模态，为快速临床转化做好了准备。PANDA可实现血红蛋白与血流的无创单模态三维成像，有助于全面评估人体深部血管动力学。
英文摘要：
Optical imaging of blood flow yields critical functional insights into the circulatory system, but its clinical implementation has typically been limited to shallow depths (~1 millimeter) due to light scattering in biological tissue. Here, we present photoacoustic noninvasive Doppler angiography (PANDA) for deep blood flow imaging. PANDA synergizes the photoacoustic and Doppler effects to generate color Doppler velocity and power Doppler blood flow maps of the vascular lumen. Our results demonstrate PANDA's ability to measure blood flow in vivo up to one centimeter in depth, marking approximately an order of magnitude improvement over existing high-resolution pure optical modalities. PANDA enhances photoacoustic flow imaging by increasing depth and enabling cross-sectional blood vessel imaging. We also showcase PANDA's clinical feasibility through three-dimensional imaging of blood flow in healthy subjects and a patient with varicose veins. By integrating the imaging system onto a mobile platform, we have designed PANDA to be a portable modality that is primed for expedient clinical translation. PANDA offers noninvasive, single modality imaging of hemoglobin and blood flow with three-dimensional capability, facilitating comprehensive assessment of deep vascular dynamics in humans.
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