利用氮掺杂超纳米金刚石光电电极实现光学神经调控
Towards optical neuromodulation using nitrogen-doped ultrananocrystalline diamond photoelectrodes
AI总结：
本研究通过氧处理调控N-UNCD表面，发现氧气炉退火可将近红外光响应提升约200倍，证明其有望用于安全限值内的光学神经刺激。
摘要：
氮掺杂超纳米金刚石（N-UNCD）是一种具有近红外光响应性的金刚石电极，非常适合生理应用。N-UNCD的光响应性受到其表面的强烈影响。虽然已知氧处理可提供更高的光响应性，但要为光学神经调控定制该材料，还需要更好地理解其表面过程。本研究考察了各种氧处理方法的影响，旨在创造具有不同化学和结构性质的富氧表面。研究采用表面表征方法以及电化学、光电化学测量和建模来研究这些薄膜。结果发现，氧气炉退火使近红外光响应性提高了数个数量级，达到3.75 ± 0.05 μA/W。这意味着与未处理表面相比，光电流约增加了200倍。光电流的这种增强主要归因于表面存在的化学物种变化。据估计，该光电流足以在安全光学暴露限值内对脑神经元进行细胞外刺激，使N-UNCD成为下一代光生物调节光电电极的优秀候选材料。
英文摘要：
Nitrogen-doped ultrananocrystalline diamond (N-UNCD) is a form of diamond electrode with near-infrared photoresponsivity, making it well suited for physiological applications. N-UNCD's photoresponsivity is strongly influenced by its surface. While it is known that oxygen treatment provides a higher photoresponsivity, a better understanding of its surface processes is needed to tailor the material for optical neuromodulation. This work examines the impact of various oxygen treatment methods, with aim of creating oxygen rich surfaces with different chemical and structural properties. Surface characterisation methods along with electrochemical and photoelectrochemical measurements and modelling were used to investigate the films. It was found that oxygen furnace annealing resulted in orders of magnitude improvement in the near-infrared photoresponsivity, to 3.75 +/- 0.05 uA/W. This translates to an approximate 200 times increase in the photocurrent compared to the untreated surface. This enhancement in photocurrent is largely due to the changes in the chemical species present at the surface. The photocurrent is estimated to be sufficient for extra-cellular stimulation of brain neurons within the safe optical exposure limit, positioning N-UNCD as an excellent candidate to be used in next-generation photoelectrodes for photobiomodulation.
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