熟悉的生物、化学和物理事件可信地演化出标准遗传密码
Familiar biological, chemical and physical events credibly evolve the Standard Genetic Code
AI总结：
本文提出基于最小选择的演化合理性指数，论证 RNA 特异性、RNPT、密码融合及逃逸扩散可分阶段可信地演化出 SGC，并解释地球生命的统一性。
摘要：
遗传密码深受起源于古老 RNA 介导相互作用的塑造，需要经历一个扩展的发展过程才能形成标准遗传密码（SGC）。这一发展可依次利用 RNA 特异性、核糖核肽转变（RNPT），以及最后的密码逃逸与扩散。一种基于最小选择的演化合理性指数同时考虑演化的速度和准确性，用以识别受青睐的演化路径。合并 RNA 世界的特异性使早期编码能够趋同至 SGC 的指派。其次，这足以启动后 RNA 世界的 RNPT。RNPT 使复杂氨基酸的生物合成成为可能，并在很大程度上依赖共存的独立密码之间晚期发生的密码融合。第三，从 RNPT 时期波动但高度进化的密码中逃逸，对进化最快、最准确/最有用的遗传密码施加了近乎理想的选择。与此同时，一种适合自由生活的密码及其微生物载体必然发生进化。地球上已确立的生命统一性很可能源于在逃离 RNPT 和密码扩散期间 SGC 取得的支配地位。
英文摘要：
The genetic code is profoundly shaped by an origin in ancient RNA-mediated interactions, needing an extended development to reach the Standard Genetic Code (SGC). That development can serially use RNA specificities, a ribonucleopeptide transition (RNPT), finally code escape and diaspora. An index of evolutionary plausibility based on least selection takes simultaneous account of speed and accuracy of evolution, identifying favored evolutions. Combining RNA world specificities allowed convergence of early coding to SGC assignments. Secondly, this was sufficient to launch a post-RNA-world RNPT. The RNPT allowed biosynthesis of complex amino acids, depending heavily on late code fusions between coexisting independent codes. Thirdly, escape from fluctuating, but highly-evolved codes of the RNPT applied a near-ideal selection for fastest-evolving and most accurate/useful genetic codes. Concurrently, a code and its microbial carrier suited to a free-living existence necessarily evolved. The established unity of life on Earth likely traces to SGC ascendancy during escape from the RNPT, and code diaspora.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
