主动环挤出对间期染色体双接触相关性的影响
Effect of active loop extrusion on the two-contact correlations in the interphase chromosome
AI总结：
本文针对单细胞中同时接触的联合统计问题，构建含随机环淬火无序的理想聚合物模型，分析主动环挤出对间期染色体双接触相关性的影响。
摘要：
由染色体构象捕获技术生成的群体平均接触图谱，提供了关于染色质基因座对之间平均接触频率随其遗传距离变化的重要信息。然而，这些数据集无法告诉我们单个细胞内基因组基因座之间同时发生接触的联合统计信息。这类统计信息可以利用单细胞 Hi-C 方法提取，该方法能够检测单个细胞内很大一部分同时接触，也可以通过现代荧光标记和超分辨成像方法获得。受相关实验数据即将可得这一前景的推动，本研究在理论上对沿单细胞接触图谱主对角线的一条垂直线上分布的接触对的联合统计进行建模。该分析是在具有随机环淬火无序的理想聚合物模型框架内进行的；如以往研究所表明的，该模型能够考虑环挤出过程对间期染色质构象性质的影响。
英文摘要：
The population-averaged contact maps generated by the chromosome conformation capture technique provide important information about the average frequency of contact between pairs of chromatin loci as a function of the genetic distance between them. However, these datasets do not tell us anything about the joint statistics of simultaneous contacts between genomic loci in individual cells. This kind of statistical information can be extracted using the single-cell Hi-C method, which is capable of detecting a large fraction of simultaneous contacts within a single cell, as well as through modern methods of fluorescent labeling and super-resolution imaging. Motivated by the prospect of the imminent availability of relevant experimental data, in this work we theoretically model the joint statistics of pairs of contacts located along a line perpendicular to the main diagonal of the single-cell contact map. The analysis is performed within the framework of an ideal polymer model with quenched disorder of random loops, which, as previous studies have shown, allows to take into account the influence of the loop extrusion process on the conformational properties of interphase chromatin.
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