向列序是否能让细长细胞群更好地感知电场？
Does nematic order allow groups of elongated cells to sense electric fields better?
AI总结：
本研究通过模拟细长细胞模型，考察向列序和细胞间黏附如何影响细胞群对电场的集体方向感知，发现强方向依赖的感知准确度下，邻近细胞长轴排列可增强响应。
摘要：
对电场等外部方向线索的集体响应在组织发育、再生和伤口愈合等过程中发挥关键作用。本研究聚焦细胞形状各向异性和局部细胞排列对电场集体响应的影响。我们对细长细胞进行建模，这些细胞感知电场的准确度取决于其相对于电场的方向。细长细胞常将长轴沿同一方向排列，即“向列序”——这是否有助于细胞群更准确地感知电场？我们通过简单模型的模拟表明，如果细胞使其自身垂直于平均速度定向，那么细胞长轴与其最近邻细胞方向的排列可以增强对电场的方向响应。然而，要使细胞从排列中获益，其感知准确度必须强烈依赖于细胞方向。我们还表明，细胞间黏附会调节群体中细胞的准确度。
英文摘要：
Collective response to external directional cues like electric fields plays a pivotal role in processes such as tissue development, regeneration, and wound healing. In this study we focus on the impact of anisotropy in cell shape and local cell alignment on the collective response to electric fields. We model elongated cells that have a different accuracy sensing the field depending on their orientation with respect to the field. Elongated cells often line up with their long axes in the same direction - "nematic order" - does this help the group of cells sense the field more accurately? We use simulations of a simple model to show that if cells orient themselves perpendicular to their average velocity, alignment of a cell's long axis to its nearest neighbors' orientation can enhance the directional response to electric fields. However, for cells to benefit from aligning, their accuracy of sensing must be strongly dependent on cell orientation. We also show that cell-cell adhesion modulates the accuracy of cells in the group.
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