从细胞交错到流动：T1转变的重要性
From cell intercalation to flow, the importance of T1 transitions
AI总结：
本文利用多相场模型研究上皮单层中T1转变对组织流动的影响，发现其平均流动呈鞍点结构并驱动涡旋流，且细胞平均分离距离随T1次数线性增加，具有参数鲁棒性。
摘要：
在上皮单层细胞的背景下，T1转变，也称为细胞交错，是细胞的一种拓扑重排，有助于上皮单层的流动性。我们使用多相场模型表明，T1转变的系综平均流动剖面呈现出鞍点结构，其中大速度局域在经历T1转变的细胞附近，从而促成涡旋流动。这种组织流化对应于细胞彼此之间的分散。虽然初始相邻细胞之间的平均配对分离距离的时间演化依赖于具体的模型细节，但平均配对分离距离随T1转变次数线性增加，这一行为对模型参数具有鲁棒性。
英文摘要：
Within the context of epithelial monolayers, T1 transitions, also known as cell-intercalations, are topological rearrangements of cells that contribute to fluidity of the epithelial monolayers. We use a multi-phase field model to show that the ensemble-averaged flow profile of a T1 transition exhibits a saddle point structure, where large velocities are localised near cells undergoing T1 transitions, contributing to vortical flow. This tissue fluidisation corresponds to the dispersion of cells relative to each other. While the temporal evolution of the mean pair-separation distance between initially neighbouring cells depends on specific model details, the mean pair-separation distance increases linearly with the number of T1 transitions, in a way that is robust to model parameters.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
