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arXiv 2403.07144cs.CL

Thought Graph:为生物推理生成思维过程

Thought Graph: Generating Thought Process for Biological Reasoning

University of Texas at Austin(德克萨斯大学奥斯汀分校);Arizona State University(亚利桑那州立大学);University of Pennsylvania(宾夕法尼亚大学);University of California San Diego(加利福尼亚大学圣迭戈分校);The University of North Carolina at Chapel Hill(北卡罗来纳大学教堂山分校);California Institute of Technology(加利福尼亚理工学院)

Chi-Yang Hsu, Kyle Cox, Jiawei Xu, Zhen Tan, Tianhua Zhai, Mengzhou Hu, Dexter Pratt, Tianlong Chen, Ziniu Hu, Ying Ding

AI总结:

本研究提出支持复杂推理的新型框架Thought Graph,以基因集分析为例揭示生物过程语义关系,在与人工标注的余弦相似度上显著优于GSEA和大语言模型基线,为生物过程命名及相关领域研究提供启示。

摘要:

我们提出Thought Graph(思维图)这一支持复杂推理的新型框架,并以基因集分析为例揭示生物过程之间的语义关系。该框架的突出优势是能深化对基因集的理解,基于与人工标注的余弦相似度,其性能显著超越GSEA达40.28%,超出大语言模型基线5.38%。我们的分析还为生物过程命名的未来方向提供了洞见,并对生物信息学和精准医学具有启示意义。

英文摘要:

We present the Thought Graph as a novel framework to support complex reasoning and use gene set analysis as an example to uncover semantic relationships between biological processes. Our framework stands out for its ability to provide a deeper understanding of gene sets, significantly surpassing GSEA by 40.28% and LLM baselines by 5.38% based on cosine similarity to human annotations. Our analysis further provides insights into future directions of biological processes naming, and implications for bioinformatics and precision medicine.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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