天然淀粉基血液仿体用于超声造影成像的回声特性研究：初步体外实验
On the Echogenicity of Natural Starch-Based Blood Mimicking Fluids for Contrast Enhanced Ultrasound Imaging: Preliminary In-vitro Experiments
AI总结：
本文通过体外实验比较了玉米、马铃薯、木薯和小麦四种天然淀粉基血液仿体在不同浓度下的回声特性，发现马铃薯淀粉基BMF回声最高，并指出高浓度淀粉BMF可用于体外造影增强超声成像。
摘要：
天然淀粉基血液仿体（BMF）已被用作商业可用BMF的替代品，用于资源有限环境下的体外多普勒研究。文献中大多数已报道的工作使用的是玉米淀粉基BMF。对其他天然淀粉作为潜在BMF的评估及其表征在文献中相对尚未被探索。为此，本研究考察了基于纯水-甘油混合液体基质、以三种不同淀粉浓度（1%、3%和5%）制备的玉米、马铃薯、木薯和小麦淀粉基BMF的回声特性。实验通过使用注射器将BMF手动泵入基于聚乙烯醇（PVA）的流动体模中进行，并使用Verasonics Vantage 128研究超声系统采集原始数据集。回声特性以波束形成图像中选定感兴趣区域（ROI）内的平均像素强度来衡量。在四种天然淀粉基BMF中，马铃薯淀粉基BMF表现出最高的回声特性和对比度，在1%、3%和5%淀粉浓度下，其像素强度（dB）分别比回声最低的BMF高出约13%、14%和10%。此外，玉米、木薯和小麦淀粉基BMF的回声特性被观察到相似，结果表明，这些具有更高淀粉浓度的BMF应用于体外造影增强超声成像。
英文摘要：
Natural starch-based blood-mimicking fluid (BMF) has been used as an alternative to commercially available BMFs for in-vitro Doppler investigations in low-resource settings. Most reported works in the literature have used corn starch-based BMF. Evaluation of other natural starches for potential BMF and their characterization have relatively been unexplored in the literature. To this end, this work investigates the echogenicity of corn-, potato-, tapioca-, and wheat starch-based BMFs prepared using a liquid base of pure water-glycerol mixture with three different starch concentrations (1%, 3%, and 5%). The experiments were performed by manually pumping the BMFs to a PolyVinyl alcohol (PVA) based flow phantom using a syringe and raw datasets were acquired using a Verasonics Vantage 128 Research Ultrasound System. Echogenicity was measured as the mean pixel intensity in a selected region of interest (ROI) in the beamformed image. Among the four natural starch-based BMFs, potato starch-based BMF showed the highest echogenicity and contrast with almost 13%, 14%, and 10% higher pixel intensities (dB) than that of the least echoic BMF with 1%, 3%, and 5% starch concentrations respectively. Moreover, the echogenicity of corn, tapioca, and wheat starch-based BMF was observed to be similar, and the results suggest that these BMFs with higher starch concentrations shall be employed for in-vitro contrast-enhanced ultrasound imaging.
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