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arXiv 2403.03368cs.LGcs.CY

利用联邦学习自动检测氯吡格雷治疗失败

Leveraging Federated Learning for Automatic Detection of Clopidogrel Treatment Failures

Cipherome Inc.(赛普洛姆公司)

Samuel Kim, Min Sang Kim

AI总结:

本研究针对氯吡格雷疗效个体差异大的问题,提出基于联邦学习的治疗失败检测方法,在UK Biobank数据集上验证其可在保护数据隐私的同时接近集中式训练性能,为医疗隐私保护下的个性化治疗提供支撑。

摘要:

氯吡格雷是一种广泛使用的抗血小板药物,其疗效在个体间差异显著,因此亟需开发精准的预测模型以优化患者护理。本研究利用联邦学习策略解决氯吡格雷治疗失败检测问题。研究发挥多家医疗机构的协作优势,使其在保护敏感患者数据的前提下联合训练机器学习模型。研究使用涵盖大量多样化人群的UK Biobank(英国生物银行)数据集,按地理中心划分数据并评估了联邦学习的性能。结果显示,尽管集中式训练能达到更高的曲线下面积(AUC)值且收敛速度更快,但联邦学习方法可大幅缩小这一性能差距。研究结果凸显了联邦学习在氯吡格雷治疗失败检测方面的潜力,为在尊重数据隐私的前提下通过个性化治疗策略提升患者护理水平提供了可行路径。本研究丰富了医疗领域联邦学习的相关研究体系,为针对多种疾病构建安全且隐私保护的预测模型奠定了基础。

英文摘要:

The effectiveness of clopidogrel, a widely used antiplatelet medication, varies significantly among individuals, necessitating the development of precise predictive models to optimize patient care. In this study, we leverage federated learning strategies to address clopidogrel treatment failure detection. Our research harnesses the collaborative power of multiple healthcare institutions, allowing them to jointly train machine learning models while safeguarding sensitive patient data. Utilizing the UK Biobank dataset, which encompasses a vast and diverse population, we partitioned the data based on geographic centers and evaluated the performance of federated learning. Our results show that while centralized training achieves higher Area Under the Curve (AUC) values and faster convergence, federated learning approaches can substantially narrow this performance gap. Our findings underscore the potential of federated learning in addressing clopidogrel treatment failure detection, offering a promising avenue for enhancing patient care through personalized treatment strategies while respecting data privacy. This study contributes to the growing body of research on federated learning in healthcare and lays the groundwork for secure and privacy-preserving predictive models for various medical conditions.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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