变色水凝胶作为集成式微流控压力传感器
Color-switching hydrogels as integrated microfluidic pressure sensors
AI总结：
本文提出一种与流路解耦的集成式光流控压力传感器，利用受压变色的机械驱动水凝胶实现非侵入、无接触的局部压力测量及二维压力成像。
摘要：
精确测量微流控流动中的压力对于流动控制、流体表征和监测至关重要，但面临实现足够分辨率、非侵入性或易用性等具体挑战。在此，我们展示了一种完全集成的多路复用光流控压力传感器，它与流路完全解耦，能够在不改变任何微流控通道流动几何形状的情况下沿通道进行局部压力测量。该传感器本身依赖于柔软的机械驱动水凝胶的压缩，通过改变颜色来响应压力变化。水凝胶通过一层薄膜与通道内循环的流体隔开，从而允许不受限制地使用不同类型的流体。使用彩色相机透过透明的PDMS对凝胶进行成像，可直接、简便且无接触地确定传感位置处的流体压力，可测压力低至20 mbar，分辨率约为10 mbar。灵敏度和可测压力范围可通过传感单元的机械性能进行调节。凭借快速响应时间和精细空间分辨率，这种光子凝胶还可用于获取二维压力或形变分布图。
英文摘要：
Precisely measuring pressure in microfluidic flows is essential for flow control, fluid characterization, and monitoring, but faces specific challenges such as \RE{achieving} sufficient resolution, non-invasiveness, or ease of use. Here, we demonstrate a fully integrated multiplexed optofluidic pressure sensor, entirely decoupled from the flow path, that enables local pressure measurements along any microfluidic channel without altering its flow geometry. The sensor itself relies on the compression of a soft mechano-actuated hydrogel, changing color in response to a pressure change. The hydrogel is separated from the fluid circulating in the channel by a thin membrane, allowing for the unrestricted use of different types of fluids. Imaging the gel through the transparent PDMS with a color camera provides a direct, easy, and contact-free determination of the fluid pressure at the sensing location for pressures as small as \SI{20}{\milli\bar} with a resolution of around \SI{10}{\milli\bar}. The sensitivity and accessible pressure range can be tuned via the mechanical properties \RE{of the sensing unit}. The photonic gel can also be used to acquire 2D pressure or deformation maps, taking advantage of the fast response time and fine spatial resolution.
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