单通道与多通道静电纺丝制备 PLA/PCL 组织工程支架：材料物理化学及生物学性能的比较研究
Single-channel and multi-channel electrospinning for the fabrication of PLA/PCL tissue engineering scaffolds: comparative study of the materials physicochemical and biological properties
AI总结：
本研究比较单通道与多通道静电纺丝制备不同质量比 PLA/PCL 支架，发现多通道方式可保留聚合物晶体结构、改变伸长率并提升干细胞黏附。
摘要：
制备具有定制物理化学和生物学特性的组织工程支架是生物医学工程中的一项重要任务。本研究聚焦于评估制备方式（单通道或多通道静电纺丝）对所制备聚乳酸（PLA）/聚（ε-己内酯）（PCL）支架性能的影响，支架采用不同聚合物质量比（1/0、2/1、1/1、1/2 和 0/1）。研究制备了具有相同形貌的支架（无论采用何种静电纺丝方式），并利用 SEM、水接触角测量、FTIR、XRD、拉伸测试以及使用多能间充质干细胞的体外实验进行表征。结果表明，多通道静电纺丝可阻止支架聚合物组分之间的分子间相互作用，保留其晶体结构，从而影响支架的力学特性（尤其导致伸长率出现2倍差异）。研究还证明，多能间充质干细胞在采用多通道静电纺丝制备的支架表面具有更好的黏附。
英文摘要：
Fabrication of tissue engineering scaffolds with tailored physicochemical and biological characteristics is a relevant task in biomedical engineering. The present work was focused at the evaluation of the effect of fabrication approach (single-channel or multi-channel electrospinning) on the properties of the fabricated poly(lactic acid)(PLA)/poly(epsilon-caprolactone)(PCL) scaffolds with various polymer mass ratios (1/0, 2/1, 1/1, 1/2, and 0/1). The scaffolds with same morphology (regardless of electrospinning variant) were fabricated and characterized using SEM, water contact angle measurement, FTIR, XRD, tensile testing and in vitro experiment with multipotent mesenchymal stem cells. It was demonstrated, that multi-channel electrospinning prevents intermolecular interactions between the polymer components of the scaffold, preserving their crystal structure, what affects the mechanical characteristics of the scaffold (particularly, leads to 2-fold difference in elongation). Better adhesion of multipotent mesenchymal stem cells on the surface of the scaffolds fabricated using multichannel electrospinning was demonstrated.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
