高聚焦微射流穿透软材料的最优驻留距离
Optimal standoff distance for a highly focused microjet penetrating a soft material
AI总结：
本研究通过实验和数值模拟，发现射流压力冲量是控制高聚焦微射流穿透软材料深度的关键参数，其峰值位置与穿透深度一致，为无针注射技术提供了优化依据。
摘要：
一种使用高聚焦微射流的无针注射器有望最大限度地减少药物递送的侵入性。在本研究中，对软材料中的射流穿透深度——这是实际无针注射中的关键参数——进行了研究。我们通过改变注射管的内径以及弯月面与软材料之间的驻留距离进行了射流穿透实验。有趣的是，结果表明穿透深度在距弯月面一定距离处达到峰值，并且随着内径的增加，峰值位置进一步远离。通过分析微射流的速度分布，发现由于射流形状的影响，穿透深度的峰值位置与最大速度的位置不一致。为了解释这一点，我们引入了“射流压力冲量”的概念，这是一个统一速度和射流形状的物理量。然而，由于时空分辨率的限制，直接从实验数据估算该参数具有挑战性。因此，我们使用数值模拟来复现实验条件并计算射流压力冲量。值得注意的是，结果表明射流压力冲量具有峰值，这与穿透深度一致。此外，射流压力冲量的大小与穿透深度之间存在相关性，突显了其作为关键参数的重要性。本研究强调了射流压力冲量在控制聚焦微射流穿透深度中的重要性，为无针注射技术的实际应用提供了有价值的见解。
英文摘要：
A needle-free injector using a highly focused microjet has the potential to minimize the invasiveness of drug delivery. In this study, the jet penetration depth in a soft material-which is a critical parameter for practical needle-free injections-was investigated. We conducted jet penetration experiments by varying the inner diameter of the injection tube and the standoff distance between the meniscus surface and the soft material. Interestingly, the results showed that the penetration depths peaked at certain distances from the meniscus, and the positions shifted further away as the inner diameter was increased. By analyzing the velocity distribution of the microjet, the peak positions of the penetration depth and the maximum velocities were inconsistent due to the effects of the jet shape. To account for this, we introduce the concept of the 'jet pressure impulse', a physical quantity that unifies the velocity and jet shape. However, direct estimation of this parameter from experimental data is challenging due to limitations in spatiotemporal resolution. Therefore, we used numerical simulations to replicate the experimental conditions and calculate the jet pressure impulse. Remarkably, the results show that the jet pressure impulse has peak values, which is consistent with the penetration depth. In addition, there is a correlation between the magnitude of the jet pressure impulse and the penetration depth, highlighting its importance as a key parameter. This study underlines the importance of the jet pressure impulse in controlling the penetration depth of a focused microjet, providing valuable insights for the practical use of needle-free injection techniques.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
