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arXiv 2402.03192stat.ME
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多重检验中使用有序p值的均匀过滤

Multiple testing using uniform filtering of ordered p-values

Zhiwen Jiang, Stephan Morgenthaler

AI总结:

本文提出一种新的自适应过滤方法,从均匀分布区域删除p值,以在备择假设罕见时控制错误发现率,并通过数据依赖的FDR选择区间中点和长度。

摘要:

我们研究了多重性模型,其中m个检验统计量的值独立地从无效应(零假设)和正效应(备择假设)的混合分布中抽取,目标是识别备择检验结果并控制错误率。我们关注备择假设罕见的情况。许多多重检验程序通过过滤有序p值集合来消除零假设。这种方法只有在备择假设产生的p值形成一个或多个可识别的簇时才有效。例如,Benjamini和Hochberg(BH)方法假设该簇出现在一个小区间$(0,Δ)$内,并过滤掉所有或大部分位于线性阈值$s \times r$之上的有序p值$p_{(r)}$。在重复应用中,该过滤器通过斜率s控制错误发现率。我们提出了一种新的自适应过滤器,它从均匀分布的区域中删除p值。在仅剩一个簇的情况下,区间内的p值被声明为备择假设,区间的中点和长度通过将数据依赖的FDR控制在期望水平来选择。

英文摘要:

We investigate the multiplicity model with m values of some test statistic independently drawn from a mixture of no effect (null) and positive effect (alternative), where we seek to identify, the alternative test results with a controlled error rate. We are interested in the case where the alternatives are rare. A number of multiple testing procedures filter the set of ordered p-values in order to eliminate the nulls. Such an approach can only work if the p-values originating from the alternatives form one or several identifiable clusters. The Benjamini and Hochberg (BH) method, for example, assumes that this cluster occurs in a small interval $(0,Δ)$ and filters out all or most of the ordered p-values $p_{(r)}$ above a linear threshold $s \times r$. In repeated applications this filter controls the false discovery rate via the slope s. We propose a new adaptive filter that deletes the p-values from regions of uniform distribution. In cases where a single cluster remains, the p-values in an interval are declared alternatives, with the mid-point and the length of the interval chosen by controlling the data-dependent FDR at a desired level.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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