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arXiv 2402.02808math.NAcs.NAphysics.bio-phq-bio.QM
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趋化模型的一种混合有限差分-粒子方法

A Hybrid Finite-Difference-Particle Method for Chemotaxis Models

Alina Chertock, Shumo Cui, Alexander Kurganov, Chenxi Wang

AI总结:

本文提出一种混合有限差分-粒子方法,用于求解趋化模型,能有效捕捉单物种和双物种系统中的爆破解行为,尤其能准确捕捉低敏感性物种的爆破解。

摘要:

趋化系统在模拟细菌和细胞行为的动力学中起着至关重要的作用,包括传播、聚集和模式形成,这些行为均受化学信号的影响。这些系统的一个显著特征是它们能够模拟浓度现象,即细胞密度在特定浓度点或沿某些曲线附近发生快速增长。这种增长可能导致奇异、尖峰结构,并引发有限时间内的爆破解。我们的研究聚焦于Patlak-Keller-Segel趋化系统及其双物种扩展的动力学。在后一种情况下,不同物种可能表现出不同的趋化敏感性,从而导致细胞密度增长率差异显著。这种情况对数值方法来说可能极具挑战性,因为它们可能因过度的数值耗散而无法准确捕捉生长较慢物种的爆破解。在本文中,我们提出了一种混合有限差分-粒子(FDP)方法,其中粒子方法用于求解趋化方程,而有限差分格式用于求解化学吸引物方程。得益于粒子方法的低耗散特性,所提出的混合格式特别擅长捕捉单物种和双物种情况下的爆破解行为。所提出的混合FDP方法在一系列具有挑战性的算例上进行了测试,获得的数值结果表明,我们的混合方法即使使用相对较少的粒子也能提供奇异结构的清晰分辨率。此外,在双物种情况下,我们的方法能够熟练地捕捉具有较低趋化敏感性的组分的爆破解,这是其他工作中未观察到的特性。

英文摘要:

Chemotaxis systems play a crucial role in modeling the dynamics of bacterial and cellular behaviors, including propagation, aggregation, and pattern formation, all under the influence of chemical signals. One notable characteristic of these systems is their ability to simulate concentration phenomena, where cell density undergoes rapid growth near specific concentration points or along certain curves. Such growth can result in singular, spiky structures and lead to finite-time blowups. Our investigation focuses on the dynamics of the Patlak-Keller-Segel chemotaxis system and its two-species extensions. In the latter case, different species may exhibit distinct chemotactic sensitivities, giving rise to very different rates of cell density growth. Such a situation may be extremely challenging for numerical methods as they may fail to accurately capture the blowup of the slower-growing species mainly due to excessive numerical dissipation. In this paper, we propose a hybrid finite-difference-particle (FDP) method, in which a particle method is used to solve the chemotaxis equation(s), while finite difference schemes are employed to solve the chemoattractant equation. Thanks to the low-dissipation nature of the particle method, the proposed hybrid scheme is particularly adept at capturing the blowup behaviors in both one- and two-species cases. The proposed hybrid FDP methods are tested on a series of challenging examples, and the obtained numerical results demonstrate that our hybrid method can provide sharp resolution of the singular structures even with a relatively small number of particles. Moreover, in the two-species case, our method adeptly captures the blowing-up solution for the component with lower chemotactic sensitivity, a feature not observed in other works.

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