镨氧化物纳米棒和纳米颗粒的多功能氧化酶样活性
Multi-functional oxidase-like activity of praseodymia nanorods and nanoparticles
AI总结：
本研究合成了镨氧化物纳米棒和纳米颗粒，其氧化酶样活性显著优于商业PrOx和多数人工酶，机制涉及空穴、氧空位和氧迁移，并成功应用于L-半胱氨酸和氟离子的高灵敏比色传感。
摘要：
利用多功能无机纳米酶模拟蛋白质基氧化酶的能力将极大地推进生物医学和临床实践。通过水热法和沉淀法合成了镨氧化物（PrOx）纳米棒（NRs）和纳米颗粒（NPs）。两种不同形貌的PrOx催化剂均表现出显著高于商业PrOx和大多数已报道的人工酶的氧化酶样活性（米氏常数Km < 0.026 mM）。其中一种底物多巴胺，在酸性条件下可被氧化并进一步聚合生成聚多巴胺。与已被广泛研究的纳米酶CeO2类似，本工作提出了涉及空穴+、氧空位和PrOx催化剂上氧迁移性的不同机制。然而，氟离子被发现对PrOx和CeO2的氧化酶模拟活性产生相反的影响，这暗示了探索新型纳米酶的有前景的路径。为此，PrOx进一步被应用于L-半胱氨酸和氟离子的比色传感，具有高灵敏度。
英文摘要：
The ability to mimic protein-based oxidase with multi-functional inorganic nanozymes would greatly advance biomedical and clinical practices. Praseodymia (PrOx) nanorods (NRs) and nanoparticles (NPs) have been synthesized using hydrothermal and precipitation methods. Both PrOx catalysts with different morphologies exhibit significantly higher oxidase-like activities (Michaelis-Menten constant Km < 0.026 mM) than commercial PrOx and most so-far-reported artificial enzymes. One of the substrates, dopamine, can be oxidized and further polymerized to generate polydopamine in acidic conditions. Akin to CeO2, which is a well-studied nanozyme, a different mechanism involving holes+, oxygen vacancies and oxygen mobility over PrOx catalysts has been proposed in this work. However, fluoride ions were found to impose opposite effects on the oxidase-mimicking activity of PrOx and CeO2, implying a promising path for the exploration of new nanozymes. In support of this, PrOx was further applied in colorimetric sensing of L-cysteine and fluoride with high sensitivity.
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