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arXiv 2402.00239stat.ME
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网络meta分析中的发表偏倚校正:一种利用临床试验注册库的逆概率加权方法

Publication bias adjustment in network meta-analysis: an inverse probability weighting approach using clinical trial registries

Ao Huang, Yi Zhou, Satoshi Hattori

AI总结:

针对网络meta分析(NMA)中存在的发表偏倚问题,提出结合t型选择函数的逆概率加权框架,利用临床试验注册库未发表研究信息求解,经数值研究和实例验证可提升估计准确性等NMA特性。

摘要:

网络meta分析(Network meta-analysis, NMA)是在单一meta分析中同时比较多种干预措施的有用工具,当研究旨在从几种有效候选方案中找出最佳疗法时,它对医疗决策非常有帮助。然而,其结果的有效性受到发表偏倚问题的威胁。现有用于标准成对meta分析中发表偏倚问题的方法,由于NMA复杂的数据结构和数据合并的潜在假设,很难扩展到该领域。本文中,我们旨在提供一个灵活的逆概率加权(inverse probability weighting, IPW)框架,结合几种t型选择函数来处理NMA场景下的发表偏倚问题。为求解这些提出的选择函数,我们建议利用来自多个临床试验注册库的未发表研究的额外信息。一项全面的数值研究和一个真实案例表明,我们的方法有助于获得更准确的估计值和更高的覆盖概率,并改善NMA的其他特性(例如干预措施排序)。

英文摘要:

Network meta-analysis (NMA) is a useful tool to compare multiple interventions simultaneously in a single meta-analysis, it can be very helpful for medical decision making when the study aims to find the best therapy among several active candidates. However, the validity of its results is threatened by the publication bias issue. Existing methods to handle the publication bias issue in the standard pairwise meta-analysis are hard to extend to this area with the complicated data structure and the underlying assumptions for pooling the data. In this paper, we aimed to provide a flexible inverse probability weighting (IPW) framework along with several t-type selection functions to deal with the publication bias problem in the NMA context. To solve these proposed selection functions, we recommend making use of the additional information from the unpublished studies from multiple clinical trial registries. A comprehensive numerical study and a real example showed that our methodology can help obtain more accurate estimates and higher coverage probabilities, and improve other properties of an NMA (e.g., ranking the interventions).

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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