细胞中性质不同的信号传导：振幅与频率编码的信息景观
Qualitatively Distinct Signaling in Cells: The Informational Landscape of Amplitude and Frequency Encoding
AI总结：
本文研究了细胞信号传导中振幅与频率编码的信息传输能力差异，指出频率编码因具有尺度不变判别能力而能在更宽范围内可靠传输信息，两种策略的组合可扩大可靠判别刺激强度的跨度。
摘要：
细胞持续感知其周围环境以检测变化并产生响应。通常，细胞外浓度的变化会引发信号级联，最终导致基因表达的改变。逐渐增加的刺激强度可以通过增加通路中间体的浓度振幅或激活频率来进行编码。本文表明，振幅和频率编码映射环境变化的不同方式，赋予了细胞性质不同的信息传输能力。振幅编码在有限的刺激强度范围内是最佳的，而频率编码则能在更宽泛的范围内以同等可靠性传输信息。这两种策略之间的性质差异源于频率编码中第一步转导步骤的尺度不变判别能力。因此，某些细胞类型中这两种策略看似冗余的组合，可能旨在扩大能够可靠判别刺激强度的跨度。本文讨论了酵母中该机制的一个可能实例。
英文摘要：
Cells continuously sense their surroundings to detect modifications and generate responses. Very often changes in extracellular concentrations initiate signaling cascades that eventually result in changes in gene expression. Increasing stimulus strengths can be encoded in increasing concentration amplitudes or increasing activation frequencies of intermediaries of the pathway. In this paper we show that the different way in which amplitude and frequency encoding map environmental changes endow cells with qualitatively different information transmission capabilities. While amplitude encoding is optimal for a limited range of stimuli strengths, frequency encoding can transmit information with equal reliability over much broader ranges. The qualitative difference between the two strategies stems from the scale invariant discriminating power of the first transducing step in frequency codification. The apparently redundant combination of both strategies in some cell types may then serve the purpose of expanding the span over which stimulus strengths can be reliably discriminated. In this paper we discuss a possible example of this mechanism in yeast.
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