探究腮腺内部PSMA配体摄取的异质性
Investigating heterogeneous PSMA ligand uptake inside parotid glands
AI总结：
本研究分析了30名前列腺癌患者的PSMA PET/CT图像，发现腮腺内PSMA PET摄取具有空间异质性，显著偏向外侧和后部区域，且该摄取模式与CT纹理特征存在显著相关性，有望作为推断摄取的替代指标。
摘要：
目的是研究前列腺特异性膜抗原（PSMA）正电子发射断层扫描（PET）在腮腺内摄取的空间异质性。我们旨在量化明确界定区域内的模式，以促进进一步研究。此外，我们还研究了摄取是否与计算机断层扫描（CT）纹理特征相关。分析了30名前列腺癌患者的[18F]DCFPyL PSMA PET/CT图像中的腮腺。使用阈值法定义高摄取区域，并在不同分区中计算摄取统计数据。利用腮腺子区域中的长运行长度强调和短运行长度强调，计算了PSMA PET摄取与灰度运行长度矩阵之间的Spearman秩相关系数。腺体外侧/后部区域的PSMA PET摄取显著高于前部/内侧区域（p < 0.001）。在60个腺体中，有50个腺体的最大摄取出现在腮腺的外侧半部。当通过一个对称分隔前部/内侧半部和后部/外侧半部的平面来划分腮腺时，两半腮腺之间的SUV差异最大。PSMA PET摄取与CT GLRLML显著相关（p < 0.001），并与CT GLRLMS显著反相关（p < 0.001）。腮腺内的PSMA PET摄取具有异质性，摄取偏向于外侧和后部区域。腮腺内的摄取模式被发现与CT纹理特征强相关，这表明未来可能将CT纹理特征用作推断唾液腺中PSMA PET摄取的替代指标。
英文摘要：
The purpose was to investigate the spatial heterogeneity of prostate-specific membrane antigen (PSMA) positron emission tomography (PET) uptake within parotid glands. We aim to quantify patterns in well-defined regions to facilitate further investigations. Furthermore, we investigate whether uptake is correlated with computed tomography (CT) texture features. Parotid glands from [18F]DCFPyL PSMA PET/CT images of 30 prostate cancer patients were analyzed. Thresholding was used to define high-uptake regions, and uptake statistics were computed within various divisions. Spearman's rank correlation coefficient was calculated between PSMA PET uptake and the Grey Level Run Length Matrix (GLRLM) using a long and short run length emphasis (GLRLML and GLRLMS) in subregions of parotid glands. PSMA PET uptake was significantly higher (p < 0.001) in lateral/posterior regions of the glands than anterior/medial regions. Maximum uptake was found in the lateral half of parotid glands in 50 out of 60 glands. The difference in SUV between parotid halves is greatest when parotids are divided by a plane separating the anterior/medial and posterior/lateral halves symmetrically. PSMA PET uptake was significantly correlated with CT GLRLML (p < 0.001), and anti-correlated with CT GLRLMS (p < 0.001). Uptake of PSMA PET is heterogeneous within parotid glands, with uptake biased towards lateral and posterior regions. Uptake patterns within parotid glands were found to be strongly correlated with CT texture features, suggesting the possible future use of CT texture features as a proxy for inferring PSMA PET uptake in salivary glands.
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