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arXiv 2312.07623cs.CV
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用于细粒度染色体识别的监督对比学习

Supervised Contrastive Learning for Fine-grained Chromosome Recognition

Hangzhou City University(杭州城市大学);Shanghai Jiao Tong University(上海交通大学);Liaoning Normal University(辽宁师范大学)

Ruijia Chang, Suncheng Xiang, Chengyu Zhou, Kui Su, Dahong Qian, Jun Wang

AI总结:

针对染色体类间相似、类内差异导致的分类难题,提出适配模型无关深度网络的监督对比学习策略,可提升特征区分度,在两个大规模数据集上使前沿模型准确率最高提升4.5%。

摘要:

染色体识别是核型分析中的一项核心任务,在出生缺陷诊断与生物医学研究中发挥着关键作用。然而,由于染色体存在类间相似性与类内差异性,现有分类方法面临着严峻挑战。为解决该问题,我们提出一种定制化的监督对比学习策略,用于训练模型无关的深度网络,以实现可靠的染色体分类。该方法可在潜在空间中提取细粒度的染色体嵌入,这些嵌入能有效拉大类别间边界、缩小类内差异,提升染色体类型预测时的特征区分度。我们在两个大规模染色体数据集上,全面验证了该对比学习策略对Transformers、ResNets等前沿深度网络的性能提升作用。大量实验结果表明,该方法可显著提升模型的泛化性能,准确率最高提升4.5%。代码与预训练模型将在本工作被接收后公开发布。

英文摘要:

Chromosome recognition is an essential task in karyotyping, which plays a vital role in birth defect diagnosis and biomedical research. However, existing classification methods face significant challenges due to the inter-class similarity and intra-class variation of chromosomes. To address this issue, we propose a supervised contrastive learning strategy that is tailored to train model-agnostic deep networks for reliable chromosome classification. This method enables extracting fine-grained chromosomal embeddings in latent space. These embeddings effectively expand inter-class boundaries and reduce intra-class variations, enhancing their distinctiveness in predicting chromosome types. On top of two large-scale chromosome datasets, we comprehensively validate the power of our contrastive learning strategy in boosting cutting-edge deep networks such as Transformers and ResNets. Extensive results demonstrate that it can significantly improve models' generalization performance, with an accuracy improvement up to +4.5%. Codes and pretrained models will be released upon acceptance of this work.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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