用于规范性铁和髓鞘分布的 chi-separation 人脑图谱
A human brain atlas of chi-separation for normative iron and myelin distributions
AI总结：
本研究利用 chi-separation 技术基于 106 个健康人脑构建规范性铁与髓鞘分布图谱，清晰描绘皮层下核团、丘脑核团和白质纤维束，并报告感兴趣区磁化率值及年龄变化，为深部脑刺激等应用提供资源。
摘要：
铁和髓鞘是人脑中主要的磁化率来源。这些物质对健康的大脑至关重要，其异常往往与多种神经系统疾病相关。最近，一种被称为 chi-separation 的先进磁化率成像技术被提出，成功地将顺磁性铁与抗磁性髓鞘分离开来。该方法为在大脑中生成高分辨率铁和髓鞘图谱提供了可能。利用该技术，本研究基于 106 个健康人脑构建了一个规范性 chi-separation 图谱。所得图谱提供了与铁和髓鞘分布相关的详细解剖结构，清晰地描绘了皮层下核团、丘脑核团和白质纤维束。此外，还报告了若干感兴趣区域的磁化率值及其随年龄变化的情况。该图谱可能具有直接应用价值，例如用于深部脑刺激或高强度聚焦超声的皮层下结构定位，同时也可作为未来研究的宝贵资源。
英文摘要：
Iron and myelin are primary susceptibility sources in the human brain. These substances are essential for healthy brain, and their abnormalities are often related to various neurological disorders. Recently, an advanced susceptibility mapping technique, which is referred to as chi-separation, has been proposed, successfully disentangling paramagnetic iron from diamagnetic myelin. This method opened a potential for generating high resolution iron and myelin maps in the brain. Utilizing this technique, this study constructs a normative chi-separation atlas from 106 healthy human brains. The resulting atlas provides detailed anatomical structures associated with the distributions of iron and myelin, clearly delineating subcortical nuclei, thalamic nuclei, and white matter fiber bundles. Additionally, susceptibility values in a number of regions of interest are reported along with age-dependent changes. This atlas may have direct applications such as localization of subcortical structures for deep brain stimulation or high-intensity focused ultrasound and also serve as a valuable resource for future research.
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