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arXiv 2311.03410cs.LGcs.AIq-bio.GN
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DP-DCAN:用于单细胞聚类的差分隐私深度对比自编码器网络

DP-DCAN: Differentially Private Deep Contrastive Autoencoder Network for Single-cell Clustering

East China Normal University(华东师范大学);Shanghai Key Laboratory of Trustworthy Computing(上海市可信计算重点实验室);Xinhua Hospital(新华医院);Shanghai Jiao Tong University(上海交通大学)

Huifa Li, Jie Fu, Zhili Chen, Xiaomin Yang, Haitao Liu, Xinpeng Ling

AI总结:

针对现有全网络扰动的差分隐私方法用于单细胞聚类时性能损耗大的问题,提出仅对部分网络加噪的DP-DCAN模型,在6个数据集上性能优于传统方案且对抗攻击鲁棒性强。

摘要:

单细胞RNA测序(scRNA-seq)对基因表达的转录组分析具有重要意义。近年来,深度学习推动了高维单细胞数据的分析。但遗憾的是,深度学习模型可能泄露用户的敏感信息,因此差分隐私(Differential Privacy,DP)越来越多地被用于隐私保护。然而,现有DP方法通常通过对整个神经网络添加扰动来实现差分隐私,会导致较大的性能损耗。为解决这一问题,本文利用自编码器仅在网络中间输出降维向量的特性,设计了面向单细胞聚类的、采用部分网络扰动的差分隐私深度对比自编码器网络(DP-DCAN)。由于仅对部分网络添加噪声,性能提升十分显著且体现在两方面:一部分网络因隐私预算更大,训练时添加的噪声更少;另一部分网络训练时完全不添加噪声。在6个数据集上的实验结果证实,DP-DCAN的性能优于传统的全网络扰动DP方案,且对对抗攻击表现出较强的鲁棒性。

英文摘要:

Single-cell RNA sequencing (scRNA-seq) is important to transcriptomic analysis of gene expression. Recently, deep learning has facilitated the analysis of high-dimensional single-cell data. Unfortunately, deep learning models may leak sensitive information about users. As a result, Differential Privacy (DP) is increasingly used to protect privacy. However, existing DP methods usually perturb whole neural networks to achieve differential privacy, and hence result in great performance overheads. To address this challenge, in this paper, we take advantage of the uniqueness of the autoencoder that it outputs only the dimension-reduced vector in the middle of the network, and design a Differentially Private Deep Contrastive Autoencoder Network (DP-DCAN) by partial network perturbation for single-cell clustering. Since only partial network is added with noise, the performance improvement is obvious and twofold: one part of network is trained with less noise due to a bigger privacy budget, and the other part is trained without any noise. Experimental results of six datasets have verified that DP-DCAN is superior to the traditional DP scheme with whole network perturbation. Moreover, DP-DCAN demonstrates strong robustness to adversarial attacks.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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