将短 DNA 弯曲建模为一系列横观各向同性环
Bending short DNAs as transversely isotropic rings in series
AI总结：
本文提出将短 DNA 的基因序列基本特征建模为一系列横观各向同性环，以解释其异常持久长度与高柔性，并表明考虑剪切的 Timoshenko 梁理论可有效描述其弯曲行为。
摘要：
尽管短 DNA 所展现的高柔性具有重要意义，但人们对其异常的持久长度仍缺乏完整理解。在本研究中，我们提出一种新方法，将短 DNA 内基因序列的每一项基本特征建模为一个横观各向同性环。我们的综合模型分析不仅成功复现了所观察到的短 DNA 高柔性，还阐明了序列依赖性的影响，并与实验结果相符。此外，分析表明，在考虑剪切因素的情况下，短 DNA 的弯曲行为可由 Timoshenko 梁理论有效描述。
英文摘要：
Despite the significance of the high flexibility exhibited by short DNAs, there remains an incomplete understanding of their anomalous persistence length. In this study, we propose a novel approach wherein each fundamental characteristic of gene sequences within short DNAs is modeled as a transversely isotropic ring. Our comprehensive model analysis not only successfully replicates the observed high flexibility of short DNAs but also sheds light on the impact of sequence dependence, aligning with experimental findings. Furthermore, our analysis suggests that the bending behavior of short DNAs can be effectively described by the Timoshenko beam theory, accounting for shear considerations.
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