Consider an advantageous allele that arises in a haploid population of size $N$ evolving in continuous time according to a skewed reproduction mechanism, which generates under neutrality genealogies lying in the domain of attraction of a Beta$(2-α, α)$-coalescent for $α\in (1,2)$. We prove in a setting of moderate selection that the fixation probability $π_N$ of the advantageous allele is asymptotically equal to $α^{1/(α-1)} s_N^{1/(α-1)} $ , where $s_N$ is the selection strength of the advantageous allele. Our proof uses duality with a suitable $Λ$-ancestral selection graph.
Fixation probabilities and hitting times under low levels of frequency-dependent selection
在群体遗传学中,单位区间上的扩散经常被用来模拟等位基因的频率路径。在这种情况下,我们得到近似的固定概率,预期的首中时和预期的网站下的频谱依赖于频率的选择。具体地说,我们重新推导和扩展了进化对策论的三分之一规则(Nowak et al.,2004)和随机减速的影响(Altrock和Traulsen,2009)。由于类似的效果在其他应用领域的兴趣,我们制定我们的结果一般一维扩散。
John A. Paulson School of Engineering and Applied Sciences, Harvard University(哈佛大学约翰·A·保尔森工程与应用科学学院);Department of Molecular and Cellular Biology, Harvard University(哈佛大学分子与细胞生物学系);Department of Organismic and Evolutionary Biology, Harvard University(哈佛大学生物体与进化生物学系);Department of Mathematics, Harvard University(哈佛大学数学系)
Logarithmic scaling of selective sweep curves: from tents to houses
Universität Wien, Fakultät für Mathematik(维也纳大学数学系);Goethe-Universität Frankfurt am Main, FB 12, Institut für Mathematik(法兰克福歌德大学数学研究所);HUN-REN Alfréd Rényi Institute of Mathematics(匈牙利科学院阿尔弗雷德·雷尼数学研究所)