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arXiv 2310.09045math.PR
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关于具有偏斜后代分布的群体中优势等位基因的固定概率

On the fixation probability of an advantageous allele in a population with skewed offspring distribution

Matthias Birkner, Florin Boenkost, Iulia Dahmer, Cornelia Pokalyuk

AI总结:

本文研究偏斜繁殖机制下优势等位基因的固定概率,在中等选择强度下证明其渐近公式为 $α^{1/(α-1)} s_N^{1/(α-1)}$,证明方法基于与 $Λ$-祖先选择图的对偶性。

摘要:

考虑一个优势等位基因出现在大小为 $N$ 的单倍体群体中,该群体在连续时间内按照偏斜繁殖机制演化,在中性条件下产生的谱系属于 Beta$(2-α, α)$-coalescent 的吸引域,其中 $α\in (1,2)$。我们在中等选择强度的设定下证明,优势等位基因的固定概率 $π_N$ 渐近等于 $α^{1/(α-1)} s_N^{1/(α-1)}$,其中 $s_N$ 是该优势等位基因的选择强度。我们的证明利用了与一个合适的 $Λ$-祖先选择图的对偶性。

英文摘要:

Consider an advantageous allele that arises in a haploid population of size $N$ evolving in continuous time according to a skewed reproduction mechanism, which generates under neutrality genealogies lying in the domain of attraction of a Beta$(2-α, α)$-coalescent for $α\in (1,2)$. We prove in a setting of moderate selection that the fixation probability $π_N$ of the advantageous allele is asymptotically equal to $α^{1/(α-1)} s_N^{1/(α-1)} $ , where $s_N$ is the selection strength of the advantageous allele. Our proof uses duality with a suitable $Λ$-ancestral selection graph.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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