We investigate the dynamics of the Red Blood Cell (RBC) in microfluidic channels under oscillatory flows. The simulations employ a hybrid continuum-particle approach, in which the cell membrane and cytosol fluid are modeled using Dissipative Particle Dynamics (DPD) method, and the blood plasma is modeled as an incompressible fluid via the Immersed Boundary Method (IBM). The goal of this study is to understand the morphological modes of the RBC under transient shear rates. Our simulations show good agreement with previous experimental and computational works. Our findings demonstrate the ability to control the transient dynamics of the RBC by adjusting the oscillatory waveform at the microchannel inlet. These results suggest that oscillatory flows can be used to manipulate cells, which may have implications for cell separation and identification of pathological cells.
A numerical lift force analysis on the inertial migration of a deformable droplet in steady and oscillatory microchannel flows at different Capillary numbers and oscillation frequencies
Dynamics of a droplet migration in oscillatory and pulsating microchannel flows and prediction and uncertainty quantification of its lateral equilibrium position using Multi Fidelity Gaussian processes
Quantifying the Biophysical Properties of Red Blood Cells in Gaucher Disease
Brown University（布朗大学）；Université Paris Saclay（巴黎萨克雷大学）；CNRS UMR 8000（法国国家科学研究中心第8000联合研究单位）；Institut de Chimie Physique（物理化学研究所）；Université Paris Cité（巴黎西岱大学）；INSERM（法国国家健康与医学研究院）；EFS（法国血液服务机构）；BIGR U1134（BIGR第1134联合研究单位）；Team BioTiGR（BioTiGR团队）；Initiatives IdEx Globule Rouge d’Excellence (InIdex GR-Ex)（卓越红细胞倡议（InIdex GR-Ex））；Team PAMS（PAMS团队）
