MyoFold：通过高度折叠序列实现快速心肌组织与运动定量
MyoFold: rapid Myocardial tissue and movement quantification via a highly Folded sequence
AI总结：
提出MyoFold磁共振序列，在12次心跳屏气内联合完成T1/T2 mapping与cine，并用神经网络定量参数，实验显示其精度可比专用序列且扫描时间缩短3倍。
摘要：
目的：开发并评估一种用于快速心肌组织和运动表征的心血管磁共振序列（MyoFold）。方法：MyoFold在12次心跳的屏气时间内，对一个左心室层面依次执行联合T1/T2 mapping和cine成像。MyoFold采用2倍加速的平衡稳态自由进动（bSSFP）进行数据读出，并采用心电图（ECG）同步心动周期。MyoFold首先在前6次心跳的舒张期采集6幅单次激发反转恢复图像。对于联合T1/T2 mapping，T2准备（T2-prep）为最后3幅图像添加不同的T2加权。在剩余6次心跳中，针对cine的每个心动相位连续执行分段bSSFP。我们构建了一个神经网络，并使用MyoFold的数值模拟对其进行训练，以计算T1和T2。MyoFold通过体模和在体实验进行验证，并与MOLLI、SASHA、T2-prep bSSFP和常规cine进行比较。结果：MyoFold体模T1存在10%的高估，而MyoFold T2具有较高准确度。MyoFold在体T1的准确度与SASHA相当，精密度与MOLLI相当。MyoFold在心肌T2测量中与T2-prep bSSFP具有良好一致性。MyoFold cine与常规cine在心肌厚度测量方面没有差异。结论：MyoFold能够同时定量心肌组织和运动，其准确度和精密度与专用序列相当，并节省3倍扫描时间。
英文摘要：
Purpose: To develop and evaluate a cardiovascular magnetic resonance sequence (MyoFold) for rapid myocardial tissue and movement characterization. Method: MyoFold sequentially performs joint T1/T2 mapping and cine for one left-ventricle slice within a breathing-holding of 12 heartbeats. MyoFold uses balanced Steady-State-Free-Precession (bSSFP) with 2-fold acceleration for data readout and adopts an electrocardiogram (ECG) to synchronize the cardiac cycle. MyoFold first acquires six single-shot inversion-recovery images at the diastole of the first six heartbeats. For joint T1/T2 mapping, T2 preparation (T2-prep) adds different T2 weightings to the last three images. On the remaining six heartbeats, segmented bSSFP is continuously performed for each cardiac phase for cine. We build a neural network and trained it using the numerical simulation of MyoFold for T1 and T2 calculations. MyoFold was validated through phantom and in-vivo experiments and compared to MOLLI, SASHA, T2-prep bSSFP, and convention cine. Results: MyoFold phantom T1 had a 10% overestimation while MyoFold T2 had high accuracy. MyoFold in-vivo T1 had comparable accuracy to that of SASHA and precision to that of MOLLI. MyoFold had good agreement with T2-prep bSSFP in myocardium T2 measurement. There was no difference in the myocardium thickness measurement between the MyoFold cine and convention cine. Conclusion: MyoFold can simultaneously quantify myocardial tissue and movement, with accuracy and precision comparable to dedicated sequences, saving three-fold scan time.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
