重建皮质脊髓束的躯体定位组织仍是现代纤维束成像方法的挑战
Reconstructing the somatotopic organization of the corticospinal tract remains a challenge for modern tractography methods
AI总结：
本研究利用人类连接组计划数据，通过四项定量指标评估六种常用纤维束成像方法重建皮质脊髓束及其躯体定位组织的性能，发现虽外侧投射重建有进展，但全面重建仍存重要挑战。
摘要：
皮质脊髓束（CST）是人脑中至关重要的白质纤维束，负责控制身体的自主运动。扩散磁共振成像（MRI）纤维束成像是唯一可用于研究健康人体中CST通路解剖结构与变异性的方法。本研究探究了六种广泛使用的纤维束成像方法在重建CST及其躯体定位组织方面的性能。我们使用Human Connectome Project（人类连接组计划）的扩散MRI数据开展实验，采用重建率、白质-灰质（WM-GM）界面覆盖度、流线解剖分布以及与皮层体积的相关性四项定量指标，评估每种方法的优势与局限性。总体而言，我们得出结论：尽管当前纤维束成像方法在改善CST外侧投射重建这一公认挑战上已取得进展，但实现CST全面重建（包括具有临床重要性的外侧（手与面部区域）和内侧部分（腿部区域）投射）的整体问题，仍是扩散MRI纤维束成像面临的一项重要挑战。
英文摘要：
The corticospinal tract (CST) is a critically important white matter fiber tract in the human brain that enables control of voluntary movements of the body. Diffusion MRI tractography is the only method that enables the study of the anatomy and variability of the CST pathway in human health. In this work, we explored the performance of six widely used tractography methods for reconstructing the CST and its somatotopic organization. We perform experiments using diffusion MRI data from the Human Connectome Project. Four quantitative measurements including reconstruction rate, the WM-GM interface coverage, anatomical distribution of streamlines, and correlation with cortical volumes to assess the advantages and limitations of each method. Overall, we conclude that while current tractography methods have made progress toward the well-known challenge of improving the reconstruction of the lateral projections of the CST, the overall problem of performing a comprehensive CST reconstruction, including clinically important projections in the lateral (hand and face area) and medial portions (leg area), remains an important challenge for diffusion MRI tractography.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
