A robust multi-domain network for short-scanning amyloid PET reconstruction
National Institute for Mathematical Sciences（数学科学国家研究院）；Department of Nuclear Medicine, Dong-A University Hospital（东阿大学医院核医学系）；College of Medicine, Dong-A University（东阿大学医学院）
This paper presents a robust multi-domain network designed to restore low-quality amyloid PET images acquired in a short period of time. The proposed method is trained on pairs of PET images from short (2 minutes) and standard (20 minutes) scanning times, sourced from multiple domains. Learning relevant image features between these domains with a single network is challenging. Our key contribution is the introduction of a mapping label, which enables effective learning of specific representations between different domains. The network, trained with various mapping labels, can efficiently correct amyloid PET datasets in multiple training domains and unseen domains, such as those obtained with new radiotracers, acquisition protocols, or PET scanners. Internal, temporal, and external validations demonstrate the effectiveness of the proposed method. Notably, for external validation datasets from unseen domains, the proposed method achieved comparable or superior results relative to methods trained with these datasets, in terms of quantitative metrics such as normalized root mean-square error and structure similarity index measure. Two nuclear medicine physicians evaluated the amyloid status as positive or negative for the external validation datasets, with accuracies of 0.970 and 0.930 for readers 1 and 2, respectively.
Cross-Modal Knowledge Distillation for PET-Free Amyloid-Beta Detection from MRI
Dublin City University（都柏林城市大学）；Insight Research Ireland Centre for Data Analytics（爱尔兰Insight研究数据分析师中心）；St. Vincent’s University Hospital（圣文森医院）；University College Dublin（都柏林大学）
A Segmentation Framework for Accurate Diagnosis of Amyloid Positivity without Structural Images
Northwest Agricultural and Forestry Science and Technology University（西北农业和林业科学与技术大学）；Liaoning Province Shiyan High School（辽宁省石yan高级中学）；Northeast Yucai School（东北育才学校）；Northeast Yucai Foreign Language School（东北育才外国语学校）
Modality Contribution Score - A Per-Patient Framework for Quantifying the Relative Diagnostic Contribution of Structural MRI and Amyloid PET in Alzheimer's Disease
Taipei Medical University（台北医学大学）；University of Memphis（孟菲斯大学）；Chitkara University（奇特卡拉大学）；University College London（伦敦大学学院）；UPES（石油与能源研究大学）；University of Eastern Finland（东芬兰大学）；CNRS（法国国家科学研究中心）；University Bordeaux（波尔多大学）；Bordeaux INP（波尔多国立理工学院）
Enhancing Alzheimer's Diagnosis: Leveraging Anatomical Landmarks in Graph Convolutional Neural Networks on Tetrahedral Meshes
School of Computing and Augmented Intelligence, Arizona State University, Tempe, AZ, USA（计算与增强智能学院，亚利桑那州立大学）；Amazon AGI, Redmond, WA, USA（亚马逊人工智慧部门）；Banner Alzheimer’s Institute, Phoenix, AZ, USA（贝纳尔德阿尔茨海默病研究所）
Synthesizing PET images from High-field and Ultra-high-field MR images Using Joint Diffusion Attention Model
Inner Mongolia University（内蒙古大学）；Inner Mongolia Medical University（内蒙古医科大学）；SIAT, Chinese Academy of Sciences（中国科学院深圳先进技术研究院）；Inner Mongolia Medical University Affiliated Hospital（内蒙古医科大学附属医院）；Shenzhen Children’s Hospital（深圳市儿童医院）
Graz University of Technology（格拉茨技术大学）；St. Pölten University of Applied Sciences（圣珀尔滕应用科学大学）；ArcTron 3D（ArcTron 3D公司）；University of Cambridge（剑桥大学）；Parco Archeologico Comunale di Seradina-Bedolina（塞拉迪纳-贝多利纳市考古公园）
The development of powerful 3D scanning hardware and reconstruction algorithms has strongly promoted the generation of 3D surface reconstructions in different domains. An area of special interest for such 3D reconstructions is the cultural heritage domain, where surface reconstructions are generated to digitally preserve historical artifacts. While reconstruction quality nowadays is sufficient in many cases, the robust analysis (e.g. segmentation, matching, and classification) of reconstructed 3D data is still an open topic. In this paper, we target the automatic and interactive segmentation o…
Positron Emission Tomography (PET) is an important tool for studying Alzheimer's disease (AD). PET scans can be used as diagnostics tools, and to provide molecular characterization of patients with cognitive disorders. However, multiple tracers are needed to measure glucose metabolism (18F-FDG), synaptic vesicle protein (11C-UCB-J), and $β$-amyloid (11C-PiB). Administering multiple tracers to patient will lead to high radiation dose and cost. In addition, access to PET scans using new or less-available tracers with sophisticated production methods and short half-life isotopes may be very limit…
RelA-Diffusion: Relativistic Adversarial Diffusion for Multi-Tracer PET Synthesis from Multi-Sequence MRI
Department of Radiology and Biomedical Research Imaging Center (BRIC), University of North Carolina at Chapel Hill（放射科与生物医学研究成像中心（BRIC）、北卡罗来纳大学教堂山分校）；Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University（生物医学工程联合部门、北卡罗来纳大学教堂山分校和北卡罗来纳州立大学）；Department of Exercise and Sport Science, UNC-CH（运动与体育科学系、UNC-CH）
Gordon Center for Medical Imaging（戈登医学影像中心）；Massachusetts General Hospital（麻省总医院）；Harvard Medical School（哈佛医学院）；Martinos Center for Biomedical Imaging（马蒂诺斯生物医学影像中心）；University of California, Davis（加州大学戴维斯分校）
Direct reconstruction methods have been developed to estimate parametric images directly from the measured PET sinograms by combining the PET imaging model and tracer kinetics in an integrated framework. Due to limited counts received, signal-to-noise-ratio (SNR) and resolution of parametric images produced by direct reconstruction frameworks are still limited. Recently supervised deep learning methods have been successfully applied to medical imaging denoising/reconstruction when large number of high-quality training labels are available. For static PET imaging, high-quality training labels c…
Cyclic 2.5D Perceptual Loss for Cross-Modal 3D Medical Image Synthesis: T1w MRI to Tau PET
Department of Artificial Intelligence, Hanyang University, Seoul, South Korea（人工智能系，翰阳大学，首尔，韩国）；Department of Electronic Engineering, Hanyang University, Seoul, South Korea（电子工程系，翰阳大学，首尔，韩国）；Division of Computer Engineering, Hankuk University of Foreign Studies, Yongin, South Korea（计算机工程系，韩国外语大学， Yongin，韩国）；Division of AI Data Convergence, Hankuk University of Foreign Studies, Yongin, South Korea（AI数据融合系，韩国外语大学， Yongin，韩国）；Division of Language & AI, Hankuk University of Foreign Studies, Seoul, South Korea（语言与AI系，韩国外语大学，首尔，韩国）
Zhejiang University（浙江大学）；Massachusetts General Hospital（麻省总医院）；Harvard Medical School（哈佛医学院）；University of Florida（佛罗里达大学）；Massachusetts General Brigham（麻省总医院布莱根医疗系统）
Deep learning based PET image reconstruction methods have achieved promising results recently. However, most of these methods follow a supervised learning paradigm, which rely heavily on the availability of high-quality training labels. In particular, the long scanning time required and high radiation exposure associated with PET scans make obtaining this labels impractical. In this paper, we propose a dual-domain unsupervised PET image reconstruction method based on learned decent algorithm, which reconstructs high-quality PET images from sinograms without the need for image labels. Specifica…
Dynamic PET Image Prediction Using a Network Combining Reversible and Irreversible Modules
Nanchang University（南昌大学）；Renji Hospital, Shanghai Jiao Tong University School of Medicine（上海交通大学医学院附属仁济医院）；The University of Edinburgh（爱丁堡大学）；Zhejiang University（浙江大学）
Image registration is an important preprocessing step in neuroimaging which allows for the matching of anatomical and functional information between modalities and subjects. This can be challenging if there are gross differences in image geometry or in signal intensity, such as in the case of some molecular PET radioligands, where control subjects display relative lack of signal relative to noise within intracranial regions, and may have off target binding that may be confused as other regions, and may vary depending on subject. The use of intermediary images or volumes have been shown to aide…
The Wellcome Centre for Human Neuroimaging, UCL（伦敦大学学院惠康人类神经影像中心）
In medical imaging it is common practice to acquire a wide range of modalities (MRI, CT, PET, etc.), to highlight different structures or pathologies. As patient movement between scans or scanning session is unavoidable, registration is often an essential step before any subsequent image analysis. In this paper, we introduce a cost function based on joint total variation for such multimodal image registration. This cost function has the advantage of enabling principled, groupwise alignment of multiple images, whilst being insensitive to strong intensity non-uniformities. We evaluate our algori…
