药物微胶囊中溶解动力学机制的可控切换
Controllable switch of dissolution kinetics mechanism in drug microcapsules
AI总结：
本文提出一种光镊结合玻璃微吸管的单颗粒-流体相互作用平台，通过局部微流控制球霰石药物微胶囊的旋转与溶解动力学，实现按需可控的药物释放速率，推动无机介孔纳米颗粒在纳米医学中的应用。
摘要：
从胶囊中可控连续释放功能材料是治疗诊断颗粒尚未实现的功能之一；在此过程中，理解体外货物-流体相互作用是一个关键里程碑。我们开发了一个灵活的平台，利用玻璃微吸管作为光学捕获颗粒周围的高度局部化流动源，研究单个颗粒与流体的相互作用。在概念验证实验中，该微粒对局部微流分布敏感，因此可作为探针使用。同样的流动能够使颗粒（即球霰石药物货物）以取决于颗粒与吸管相互位置的频率旋转。该平台的灵活性源于光镊（光学力）和吸管（机械/流体动力学）与微粒的不同相互作用，这使得该装置成为一种理想的微型工具。我们研究了球霰石的溶解动力学，并证明其可以按需控制，从而提供宽范围的货物释放动态速率。我们的结果推动了无机介孔纳米颗粒作为纳米医学平台的应用。
英文摘要：
Controllable continuous release of functional materials from capsules is one of the unmet functions of theragnosis particles; on this way, understanding cargo-fluid interactions in vitro is an essential milestone. We develop a flexible platform to investigate single particle-fluid interactions utilizing a glass micropipette as a highly localized flow source around an optically trapped particle. In proof-of-concept experiments this microparticle is sensitive to local microflows distribution, thus serving as a probe. The very same flows are capable of the particle rotating (i.e., vaterite drug cargo) at frequencies dependent on the mutual particle-pipette position. The platform flexibility comes from different interactions of a tweezer (optical forces) and a pipette (mechanical/hydrodynamical) with micro-particle, which makes this arrangement an ideal micro-tool. We studied the vaterite dissolution kinetics and demonstrated it can be controlled on demand, providing a wide cargo release dynamic rate. Our results promote using inorganic mesoporous nanoparticles as a nanomedicine platform.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
