蛋白质序列的三维混沌博弈表示
Three dimensional chaos game representation of protein sequences
摘要：
本论文探索了一种新的蛋白质序列混沌博弈的三维表示方法。介绍了DNA的基础知识、从DNA合成蛋白质、蛋白质结构和功能以及序列比对技术。简要讨论了理解混沌博弈表示和分形分析所需的数学背景。介绍了DNA序列的混沌博弈表示的现有文献，详细介绍了二维蛋白质序列的混沌博弈表示及其优点和局限性。我们探索了一种新的蛋白质序列的混沌博弈三维表示方法（3D-CGR），并研究了它的能力：a）确定蛋白质序列的相似性和差异; b）研究氨基酸水平上的二核苷酸偏差对3D-CGR衍生的蛋白质同源性的影响; c）基于重排基序的序列相似性识别，可用于研究外显子重排引起的蛋白质进化。
英文摘要：
A new three dimensional approach to the chaos game representation of protein sequences is explored in this thesis. The basics of DNA, the synthesis of proteins from DNA, protein structure and functionality and sequence alignment techniques are presented. The mathematical background needed for understanding the chaos game representation and fractal analysis are briefly discussed. An account of the existing literature on the chaos game representation of DNA sequences and a detailed account of the chaos game representation of protein sequences in two dimensions with its advantages and limitations are presented. We explore a new three dimensional approach to the chaos game representation of protein sequences (3D-CGR) and study its ability a) to determine protein sequence similarity and differences, b) to study the effect of dinucleotide biases at amino acid level on the 3D-CGR derived protein homology, and c) to identify sequence similarity based on shuffled motifs that could be used for studying protein evolution due to exon shuffling.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
