胁迫诱导的突变可以进一步提高静态生态学中的种群成功率
Stress-Induced Mutagenesis Can Further Boost Population Success in Static Ecology
摘要：
我们已经开发了一个数学模型，捕获应力诱导的诱变，致病性和肿瘤性演化动力学的一个基本方面，在适应度景观与多个相关的遗传性状作为一个高维欧氏空间。在这个框架下，应力诱导的诱变表现为一个异质扩散过程。我们展示了如何增加突变，从而减少剥削，在一个静态的生态与固定的承载能力和最大增长率，可以矛盾地提高人口规模。值得注意的是，这种意想不到的生物物理现象普遍适用于任何数量的性状。
英文摘要：
We have developed a mathematical model that captures stress-induced mutagenesis, a fundamental aspect of pathogenic and neoplastic evolutionary dynamics, on the fitness landscape with multiple relevant genetic traits as a high-dimensional Euclidean space. In this framework, stress-induced mutagenesis manifests as a heterogeneous diffusion process. We show how increasing mutations, and thus reducing exploitation, in a static ecology with fixed carrying capacity and maximum growth rates, can paradoxically boost population size. Remarkably, this unexpected biophysical phenomenon applies universally to any number of traits.
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