群体感应协同给药的分子通讯
Molecular Communication for Quorum Sensing Inspired Cooperative Drug Delivery
摘要：
提出了一种协同给药系统，其中群体感应（QS），一种密度依赖性细菌行为协调机制，由基于合成细菌的纳米机器（B-NM）用于可控的药物递送。在我们提出的系统中，只有当有足够的QS分子时才会触发药物递送，而这反过来又只有当有足够的B-NM时才会发生。这使得所提出的系统可以用于在B-NM的群体密度可能未知时实现药物分子从大量B-NM的高释放速率。推导出了i）由于随机分布的B-NM引起的B-NM的预期活化概率和ii）由于随机分布的QS活化的B-NM引起的药物分子的预期聚集体吸收率的解析表达式。基于粒子的模拟验证了分析结果。推导的结果可以帮助预测和控制环境因素（如扩散系数和降解速率）对药物分子的吸收速率的影响，因为严格的扩散为基础的分子通道被认为是。我们的研究结果表明，在B-NM的激活概率增加，因为这个B-NM位于更接近的中心的B-NM人口和聚集体的药物分子的吸收率非线性增加的人口密度增加。
英文摘要：
A cooperative drug delivery system is proposed, where quorum sensing (QS), a density-dependent bacterial behavior coordination mechanism, is employed by synthetic bacterium-based nanomachines (B-NMs) for controllable drug delivery. In our proposed system, drug delivery is only triggered when there are enough QS molecules, which in turn only happens when there are enough B-NMs. This makes the proposed system can be used to achieve a high release rate of drug molecules from a high number of B-NMs when the population density of B-NMs may not be known. Analytical expressions for i) the expected activation probability of the B-NM due to randomly-distributed B-NMs and ii) the expected aggregate absorption rate of drug molecules due to randomly-distributed QS activated B-NMs are derived. Analytical results are verified by particle-based simulations. The derived results can help to predict and control the impact of environmental factors (e.g. diffusion coefficient and degradation rate) on the absorption rate of drug molecules since rigorous diffusion-based molecular channels are considered. Our results show that the activation probability at the B-NM increases as this B-NM is located closer to the center of the B-NM population and the aggregate absorption rate of the drug molecules non-linearly increases as the population density increases.
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