作为红细胞仿生模型的超软可调PDMS微胶囊的稳健制备
Robust fabrication of ultra-soft tunable PDMS microcapsules as a biomimetic model for red blood cells
AI总结：
本研究利用三维嵌套玻璃毛细管装置稳健制备单分散可调超软PDMS微胶囊，经渗透收缩后可仿生红细胞的流动变形特性，为微血流动力学研究提供工具，也可拓展应用于其他领域。
摘要：
具有薄膜包裹液核的微胶囊在科学、医学和工业领域有诸多应用。本文设计了一种能像红细胞（RBCs）一样流动和变形的微胶囊悬浮液，作为研究微血流动力学的重要工具。研究采用可重构、易组装的三维嵌套玻璃毛细管装置，稳健地制备水-油-水双重乳液，随后通过交联包裹液滴的聚二甲基硅氧烷（PDMS，聚二甲基硅氧烷）层，将其转化为具有超弹性膜的球形微胶囊。所得微胶囊的单分散性误差在1%以内，可制备的尺寸和膜厚度范围广。为匹配双凹形红细胞的约化体积，研究利用渗透作用将初始直径350μm、膜厚度为半径4%的球形微胶囊收缩36%。研究对比了初始球形和收缩后的微胶囊在不同约束程度的圆柱形毛细管中、恒定体积流量下的传输行为。结果发现，只有收缩后的微胶囊在相近的毛细管数（Ca，即粘性力与弹性力之比）范围内，变形行为与红细胞大致相似。与红细胞类似，在生理范围内的Ca增大时，微胶囊会从对称的“降落伞”形转变为不对称的“拖鞋”形，展现出引人关注的约束依赖动力学特性。除了仿生红细胞的特性，高通量制备的可调超软微胶囊还可进一步功能化，在科学与工程的其他领域得到应用。
英文摘要：
Microcapsules with liquid cores encapsulated by thin membranes have many applications in science, medicine and industry. In this paper, we design a suspension of microcapsules which flow and deform like red blood cells (RBCs), as a valuable tool to investigate microhaemodynamics. A reconfigurable and easy-to-assemble 3D nested glass capillary device is used to robustly fabricate water-oil-water double emulsions which are then converted into spherical microcapsules with hyperelastic membranes by cross-linking the polydimethylsiloxane (PDMS) layer coating the droplets. The resulting capsules are monodisperse to within 1% and can be made in a wide range of size and membrane thickness. We use osmosis to deflate by 36% initially spherical capsules of diameter 350 μm and a membrane thickness of 4% of their radius, in order to match the reduced volume of biconcave RBCs. We compare the propagation of initially spherical and deflated capsules under constant volumetric flow in cylindrical capillaries of different confinements. We find that only deflated capsules deform broadly similarly to RBCs over a similar range of capillary numbers (Ca) -- the ratio of viscous to elastic forces. Similarly to the RBCs, the microcapsules transition from a symmetric 'parachute' to an asymmetric 'slipper'-like shape as Ca increases within the physiological range, demonstrating intriguing confinement-dependent dynamics. In addition to biomimetic RBC properties, high-throughput fabrication of tunable ultra-soft microcapsules could be further functionalized and find applications in other areas of science and engineering
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