骨髓增生性肿瘤突变次序问题的数学模型：非加性和非交换性
Mathematical models for order of mutation problem in myeloproliferative neoplasm: non-additivity and non-commutativity
摘要：
在一些骨髓增生性肿瘤患者中，可以发现两种基因突变：JAK2 V617 F和TET2。当一个突变存在或不存在时，另一个突变对调节基因表达具有不同的作用。此外，当两种突变都存在时，发生的顺序可能会有所不同。本文建立了非线性常微分方程模型和马尔可夫链模型来解释这一现象。
英文摘要：
In some patients of myeloproliferative neoplasm, two genetic mutations can be found: JAK2 V617F and TET2. When one mutation is present or not, the other mutation has different effects on regulating gene expressions. Besides, when both mutations are present, the order of occurrence might make a difference. In this paper, we build nonlinear ordinary differential equation models and Markov chain models to explain such phenomena.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
