arXivDaily arXiv每日学术速递 周一至周五更新
arXiv 2302.01367stat.MLcs.LGstat.ME

Augmented Learning of Heterogeneous Treatment Effects via Gradient Boosting Trees

Gilead Sciences, Inc.(吉利德科学公司);Fred Hutchinson Cancer Center(弗雷德·哈钦森癌症中心);University of Washington(华盛顿大学)

Heng Chen, Michael L. LeBlanc, James Y. Dai

英文摘要:

Heterogeneous treatment effects (HTE) based on patients' genetic or clinical factors are of significant interest to precision medicine. Simultaneously modeling HTE and corresponding main effects for randomized clinical trials with high-dimensional predictive markers is challenging. Motivated by the modified covariates approach, we propose a two-stage statistical learning procedure for estimating HTE with optimal efficiency augmentation, generalizing to arbitrary interaction model and exploiting powerful extreme gradient boosting trees (XGBoost). Target estimands for HTE are defined in the scale of mean difference for quantitative outcomes, or risk ratio for binary outcomes, which are the minimizers of specialized loss functions. The first stage is to estimate the main-effect equivalency of the baseline markers on the outcome, which is then used as an augmentation term in the second stage estimation for HTE. The proposed two-stage procedure is robust to model mis-specification of main effects and improves efficiency for estimating HTE through nonparametric function estimation, e.g., XGBoost. A permutation test is proposed for global assessment of evidence for HTE. An analysis of a genetic study in Prostate Cancer Prevention Trial led by the SWOG Cancer Research Network, is conducted to showcase the properties and the utilities of the two-stage method.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

↑