Temporal-lobe Epilepsy: Harmonic and Anharmonic Periodicity in Microeletrode Voltage
英文摘要：
Temporal-lobe epilepsy in humans is often associated with widespread, synchronized neuron firing that co-occurs with traveling waves in local field potential. These traveling waves generate stochastic oscillations in a time series of microelectrode voltage, and previous work has deemed it informative for traveling-wave analysis to study the mean periodicity. This manuscript reveals that: a) mean voltage (i.e., traveling-wave periodicity) adequately explains the observed voltage periodicity only for a select few time intervals during seizure; and b) mean voltage has a 7 Hz cosine-series representation indicative of a nonlinear system response given alpha-rhythm input. The a) result implies that residual noise should be modelled explicitly, while b) motivates a departure from the conventional plane-wave modeling regime in source-localization efforts. The 7 Hz fundamental frequency is unsurprising given the relative transparency of the brain to 14 Hz alpha rhythms in neurophysiological diseases (14 Hz being a subharmonic frequency of the 7 Hz signal).
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