Background: Clear cell renal cell carcinoma (ccRCC) is the most common renal-related tumor with high heterogeneity. There is still an urgent need for novel diagnostic and prognostic biomarkers for ccRCC. Methods: We proposed a weakly-supervised deep learning strategy using conventional histology of 1752 whole slide images from multiple centers. Our study was demonstrated through internal cross-validation and external validations for the deep learning-based models. Results: Automatic diagnosis for ccRCC through intelligent subtyping of renal cell carcinoma was proved in this study. Our graderisk achieved aera the curve (AUC) of 0.840 (95% confidence interval: 0.805-0.871) in the TCGA cohort, 0.840 (0.805-0.871) in the General cohort, and 0.840 (0.805-0.871) in the CPTAC cohort for the recognition of high-grade tumor. The OSrisk for the prediction of 5-year survival status achieved AUC of 0.784 (0.746-0.819) in the TCGA cohort, which was further verified in the independent General cohort and the CPTAC cohort, with AUC of 0.774 (0.723-0.820) and 0.702 (0.632-0.765), respectively. Cox regression analysis indicated that graderisk, OSrisk, tumor grade, and tumor stage were found to be independent prognostic factors, which were further incorporated into the competing-risk nomogram (CRN). Kaplan-Meier survival analyses further illustrated that our CRN could significantly distinguish patients with high survival risk, with hazard ratio of 5.664 (3.893-8.239, p < 0.0001) in the TCGA cohort, 35.740 (5.889-216.900, p < 0.0001) in the General cohort and 6.107 (1.815 to 20.540, p < 0.0001) in the CPTAC cohort. Comparison analyses conformed that our CRN outperformed current prognosis indicators in the prediction of survival status, with higher concordance index for clinical prognosis.
Xi’an Jiaotong University（西安交通大学）；Pennsylvania State University（宾夕法尼亚州立大学）；the First Affiliated Hospital of Xi’an Jiaotong University（西安交通大学第一附属医院）
Diagnostic pathology, which is the basis and gold standard of cancer diagnosis, provides essential information on the prognosis of the disease and vital evidence for clinical treatment. Tumor region detection, subtype and grade classification are the fundamental diagnostic indicators for renal cell carcinoma (RCC) in whole-slide images (WSIs). However, pathological diagnosis is subjective, differences in observation and diagnosis between pathologists is common in hospitals with inadequate diagnostic capacity. The main challenge for developing deep learning based RCC diagnostic system is the la…
Geisel School of Medicine at Dartmouth（达特茅斯盖泽尔医学院）；Dartmouth-Hitchcock Medical Center（达特茅斯-希契科克医疗中心）；Dartmouth College（达特茅斯学院）
Renal cell carcinoma (RCC) is the most common renal cancer in adults. The histopathologic classification of RCC is essential for diagnosis, prognosis, and management of patients. Reorganization and classification of complex histologic patterns of RCC on biopsy and surgical resection slides under a microscope remains a heavily specialized, error-prone, and time-consuming task for pathologists. In this study, we developed a deep neural network model that can accurately classify digitized surgical resection slides and biopsy slides into five related classes: clear cell RCC, papillary RCC, chromop…
Obtaining a large amount of labeled data in medical imaging is laborious and time-consuming, especially for histopathology. However, it is much easier and cheaper to get unlabeled data from whole-slide images (WSIs). Semi-supervised learning (SSL) is an effective way to utilize unlabeled data and alleviate the need for labeled data. For this reason, we proposed a framework that employs an SSL method to accurately detect cancerous regions with a novel annotation method called Minimal Point-Based annotation, and then utilize the predicted results with an innovative hybrid loss to train a classif…
Clear cell renal cell carcinoma (ccRCC) is one of the most common forms of intratumoral heterogeneity in the study of renal cancer. ccRCC originates from the epithelial lining of proximal convoluted renal tubules. These cells undergo abnormal mutations in the presence of Ki67 protein and create a lump-like structure through cell proliferation. Manual counting of tumor cells in the tissue-affected sections is one of the strongest prognostic markers for renal cancer. However, this procedure is time-consuming and also prone to subjectivity. These assessments are based on the physical cell appeara…
The grade of clear cell renal cell carcinoma (ccRCC) is a critical prognostic factor, making ccRCC nuclei grading a crucial task in RCC pathology analysis. Computer-aided nuclei grading aims to improve pathologists' work efficiency while reducing their misdiagnosis rate by automatically identifying the grades of tumor nuclei within histopathological images. Such a task requires precisely segment and accurately classify the nuclei. However, most of the existing nuclei segmentation and classification methods can not handle the inter-class similarity property of nuclei grading, thus can not be di…
MeD-3D: A Multimodal Deep Learning Framework for Precise Recurrence Prediction in Clear Cell Renal Cell Carcinoma (ccRCC)
Skolkovo Institute of Science and Technology (Skoltech)（斯克罗夫诺科学与技术学院（Skoltech））；German Research Center for Artificial Intelligence (DFKI)（德国人工智能研究中心（DFKI））
Renal cell carcinoma (RCC) is a common cancer that varies in clinical behavior. Indolent RCC is often low-grade without necrosis and can be monitored without treatment. Aggressive RCC is often high-grade and can cause metastasis and death if not promptly detected and treated. While most kidney cancers are detected on CT scans, grading is based on histology from invasive biopsy or surgery. Determining aggressiveness on CT images is clinically important as it facilitates risk stratification and treatment planning. This study aims to use machine learning methods to identify radiology features tha…
Purpose: To identify optimal classification methods for computed tomography (CT) radiomics-based preoperative prediction of clear cells renal cell carcinoma (ccRCC) grade. Methods and material: Seventy one ccRCC patients were included in the study. Three image preprocessing techniques (Laplacian of Gaussian, wavelet filter, and discretization of the intensity values) were applied on tumor volumes. In total, 2530 radiomics features (tumor shape and size, intensity statistics, and texture) were extracted from each segmented tumor volume. Univariate analysis was performed to assess the associatio…
Renal cell carcinoma (RCC) is a type of cancer that originates in the kidneys and is the most common type of kidney cancer in adults. It can be classified into several subtypes, including clear cell RCC, papillary RCC, and chromophobe RCC. In this study, an artificial intelligence model was developed and trained for classifying different subtypes of RCC using ResNet-18, a convolutional neural network that has been widely used for image classification tasks. The model was trained on a dataset of RCC histopathology images, which consisted of digital images of RCC surgical resection slides that w…
Beyond Discrimination: Evaluating Probability Calibration in Radiomics-Image Fusion for Renal Cell Carcinoma Classification
Research Ireland Centre for Research Training in Machine Learning（爱尔兰研究机器学习研究中心）；ML-Labs（机器学习实验室）；School of Computer Science, University College Dublin（都柏林大学计算机学院）；School of Computer Science, Technological University Dublin（都柏林理工大学计算机学院）；School of Veterinary Medicine, University College Dublin（都柏林大学兽医学院）；School of Computing, Dublin City University（都柏林城市大学计算机学院）
Institute of Imaging and Computer Vision, RWTH Aachen University（亚琛工业大学成像与计算机视觉研究所）；Heinrich Heine University Düsseldorf（杜塞尔多夫海因里希·海涅大学）；Institute of Medical Sciences, Kermanshah University（克尔曼沙阿大学医学研究所）
A Robust Deep Learning Method with Uncertainty Estimation for the Pathological Classification of Renal Cell Carcinoma based on CT Images
School of Computer and Communication Engineering, Zhengzhou University of Light Industry（郑州轻工业大学计算机与通信工程学院）；Sun Yat-Sen University Cancer Center（中山大学肿瘤防治中心）；Michigan Technological University（密歇根理工大学）；The First People's Hospital of Guangzhou（广州市第一人民医院）
Unraveling Radiomics Complexity: Strategies for Optimal Simplicity in Predictive Modeling
Université de Sherbrooke（谢布鲁克大学）；OncoRay – National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Helmholtz-Zentrum Dresden-Rossendorf（德累斯顿工业大学卡尔·古斯塔夫·卡鲁斯医学院及大学医院OncoRay肿瘤放射研究国家中心，德累斯顿-罗森多夫亥姆霍兹研究中心）；Cedars-Sinai Medical Center（西达赛奈医疗中心）；University of California San Francisco（加利福尼亚大学旧金山分校）；Stanford University（斯坦福大学）
Nasopharyngeal Carcinoma (NPC) is endemic cancer in the south-east Asia. With the advent of intensity-modulated radiotherapy excellent locoregional control are being achieved. Consequently, this had led to pretreatment clinical staging classification to be less prognostic of outcomes such as recurrence after treatment. Alternative pretreatment strategies for prognosis of NPC after treatment are needed to provide better risk stratification for NPC. In this study we proposed a deep convolution neural network model based on contrast-enhanced T1 (T1C) and T2 weighted (T2) MRI scan to predict 3-yea…
Huron Digital Pathology（休伦数字病理学公司）；University of Waterloo（滑铁卢大学）；Vector Institute（矢量研究所）；McMaster University（麦克马斯特大学）；University of Pittsburgh Medical Center（匹兹堡大学医学中心）
The emergence of digital pathology has opened new horizons for histopathology and cytology. Artificial-intelligence algorithms are able to operate on digitized slides to assist pathologists with diagnostic tasks. Whereas machine learning involving classification and segmentation methods have obvious benefits for image analysis in pathology, image search represents a fundamental shift in computational pathology. Matching the pathology of new patients with already diagnosed and curated cases offers pathologist a novel approach to improve diagnostic accuracy through visual inspection of similar c…
Predicting brain tumour enhancement from non-contrast MR imaging with artificial intelligence: a multi-cohort retrospective diagnostic accuracy study
Queen Square Institute of Neurology, University College London, London, UK（伦敦大学学院医院神经科学研究所）；National Hospital for Neurology and Neurosurgery, London, UK（伦敦神经病学与神经外科医院）；NVIDIA, UK（英国NVIDIA公司）；Great Ormond Street Hospital for Children, London, UK（伦敦儿童医院）；Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK（斯坦莫尔皇家骨科医院，中西敏，英国）；University College Hospitals NHS Foundation Trust, London, UK（伦敦大学学院医院 NHS 基础信托）；Royal Free Hospital, London, UK（伦敦皇家自由医院）；Imperial College Healthcare NHS Trust, London, UK（伦敦帝国学院医疗信托）；Imperial College London, London, UK（伦敦帝国学院）
MMIST-ccRCC: A Real World Medical Dataset for the Development of Multi-Modal Systems
Institute for Systems and Robotics（系统与机器人研究所）；Instituto Superior Técnico（高等技术学院）；Institute of Computing（计算机研究所）；University of Campinas（坎皮纳斯大学）；Lisbon ELLIS Unit（里斯本ELLIS单元）
