辐射暴露基因表达谱的综合分析揭示了低剂量辐射反应的分子特征
Comprehensive analysis of gene expression profiles to radiation exposure reveals molecular signatures of low-dose radiation response
摘要：
电离辐射照射有各种来源，其中用于放射治疗或诊断的医疗照射是最常见的人为来源。了解电离辐射暴露后基因表达是如何调节的，并调查任何剂量依赖性基因表达模式的存在，对放疗、医疗辐射诊断程序以及其他环境暴露的健康风险具有广泛的意义。在本文中，我们进行了全面的基于路径的分析基因表达档案在低剂量辐射暴露，以检查潜在的基因调控的机制，这种反应。为了实现这一目标，我们采用了一个统计框架，以确定是否属于一个已知的途径显示协调的表达模式，调制的方式与辐射水平一致的一组特定的基因。我们的研究结果表明，存在复杂但一致的特征，反映了对辐射暴露的分子反应，这在低剂量和高剂量辐射之间是不同的。
英文摘要：
There are various sources of ionizing radiation exposure, where medical exposure for radiation therapy or diagnosis is the most common human-made source. Understanding how gene expression is modulated after ionizing radiation exposure and investigating the presence of any dose-dependent gene expression patterns have broad implications for health risks from radiotherapy, medical radiation diagnostic procedures, as well as other environmental exposure. In this paper, we perform a comprehensive pathway-based analysis of gene expression profiles in response to low-dose radiation exposure, in order to examine the potential mechanism of gene regulation underlying such responses. To accomplish this goal, we employ a statistical framework to determine whether a specific group of genes belonging to a known pathway display coordinated expression patterns that are modulated in a manner consistent with the radiation level. Findings in our study suggest that there exist complex yet consistent signatures that reflect the molecular response to radiation exposure, which differ between low-dose and high-dose radiation.
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