通过通道间因果关系研究发展性阅读障碍的神经源/汇相连接
Neural source/sink phase connectivity in developmental dyslexia by means of interchannel causality
摘要：
虽然大脑连接网络可以为发展性阅读障碍的理解和诊断提供信息，但其因果关系尚未得到足够的研究。采用脑电信号和带限白噪声刺激在4.8 Hz（韵律音节频率），我们测量通道之间的相位格兰杰因果关系，以确定学习障碍的学习者和控制之间的差异，从而提出了一种方法来计算方向连接。由于因果关系在两个方向上运行，我们探讨三种情况，即渠道的活动作为源，作为汇，并在总。我们提出的方法可以用于分类和探索性分析。在所有的情况下，我们发现确认建立的右侧Theta采样网络异常，符合时间采样框架的假设，在Theta和Gamma波段的振荡差异。此外，我们表明，这种异常主要发生在因果关系的渠道作为汇，它是显着更明显的比只有总活动时，观察。在水槽的情况下，我们的分类器获得0.84和0.88的准确度和0.87和0.93 AUC的Theta和Gamma波段，分别。
英文摘要：
While the brain connectivity network can inform the understanding and diagnosis of developmental dyslexia, its cause-effect relationships have not yet enough been examined. Employing electroencephalography signals and band-limited white noise stimulus at 4.8 Hz (prosodic-syllabic frequency), we measure the phase Granger causalities among channels to identify differences between dyslexic learners and controls, thereby proposing a method to calculate directional connectivity. As causal relationships run in both directions, we explore three scenarios, namely channels' activity as sources, as sinks, and in total. Our proposed method can be used for both classification and exploratory analysis. In all scenarios, we find confirmation of the established right-lateralized Theta sampling network anomaly, in line with the temporal sampling framework's assumption of oscillatory differences in the Theta and Gamma bands. Further, we show that this anomaly primarily occurs in the causal relationships of channels acting as sinks, where it is significantly more pronounced than when only total activity is observed. In the sink scenario, our classifier obtains 0.84 and 0.88 accuracy and 0.87 and 0.93 AUC for the Theta and Gamma bands, respectively.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
