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arXiv 2212.01064math.OCmath.AP
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一类抛物型神经胶质瘤治疗模型的最优控制问题

Optimal control problems for a parabolic system modeling glioma therapy

Mauro Garavello, Elena Rossi

摘要:

在本文中,我们考虑的最优控制问题的抛物系统建模的治疗,基于溶瘤病毒,神经胶质瘤脑癌。使用几种典型的技术泛函分析,我们证明了全球的时间适定性的控制模型,存在最优控制特定的目标泛函,这是自然的癌症治疗,我们推导出必要条件的最优性。

英文摘要:

In this paper we consider optimal control problems for a parabolic system modeling a therapy, based on oncolytic viruses, for the glioma brain cancer. Using several techniques typical of functional analysis, we prove the global in time well posedness of the control model, the existence of optimal controls for specific objective functionals, which are natural for cancer therapies, and we derive necessary conditions for optimality.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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