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arXiv 2209.15399cs.LGcs.AIq-bio.QM
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Parea:用于癌症亚型发现的多视图集成聚类

Parea: multi-view ensemble clustering for cancer subtype discovery

Medical University Graz(格拉茨医科大学)

Bastian Pfeifer, Marcus D. Bloice, Michael G. Schimek

摘要:

多视图聚类方法对于将患者分层为具有相似分子特征的亚组是必不可少的。近年来,为此目的开发了各种各样的方法。然而,由于癌症相关数据的高度多样性,单一方法可能无法在所有情况下都表现得足够好。我们提出了Parea,一个多视图层次集成聚类方法的疾病亚型发现。我们在几个机器学习基准数据集上展示了它的性能。我们应用并验证我们的方法对现实世界的多视图癌症患者数据。Parea在七种分析的癌症类型中的六种上的表现优于目前的最新技术水平。我们已经将Parea方法集成到我们开发的Python包Pyrea(https://github.com/mdbloice/Pyrea)中,它可以轻松灵活地设计集成工作流,同时集成各种融合和聚类算法。

英文摘要:

Multi-view clustering methods are essential for the stratification of patients into sub-groups of similar molecular characteristics. In recent years, a wide range of methods has been developed for this purpose. However, due to the high diversity of cancer-related data, a single method may not perform sufficiently well in all cases. We present Parea, a multi-view hierarchical ensemble clustering approach for disease subtype discovery. We demonstrate its performance on several machine learning benchmark datasets. We apply and validate our methodology on real-world multi-view cancer patient data. Parea outperforms the current state-of-the-art on six out of seven analysed cancer types. We have integrated the Parea method into our developed Python package Pyrea (https://github.com/mdbloice/Pyrea), which enables the effortless and flexible design of ensemble workflows while incorporating a wide range of fusion and clustering algorithms.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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