Shape restrictions on functional regression coefficients such as non-negativity, monotonicity, convexity or concavity are often available in the form of a prior knowledge or required to maintain a structural consistency in functional regression models. A new estimation method is developed in shape-constrained functional regression models using Bernstein polynomials. Specifically, estimation approaches from nonparametric regression are extended to functional data, properly accounting for shape-constraints in a large class of functional regression models such as scalar-on-function regression (SOFR), function-on-scalar regression (FOSR), and function-on-function regression (FOFR). Theoretical results establish the asymptotic consistency of the constrained estimators under standard regularity conditions. A projection based approach provides point-wise asymptotic confidence intervals for the constrained estimators. A bootstrap test is developed facilitating testing of the shape constraints. Numerical analysis using simulations illustrate improvement in efficiency of the estimators from the use of the proposed method under shape constraints. Two applications include i) modeling a drug effect in a mental health study via shape-restricted FOSR and ii) modeling subject-specific quantile functions of accelerometry-estimated physical activity in the Baltimore Longitudinal Study of Aging (BLSA) as outcomes via shape-restricted quantile-function on scalar regression (QFOSR). R software implementation and illustration of the proposed estimation method and the test is provided.
This paper brings a contribution to the Bayesian theory of nonparametric and semiparametric estimation. We are interested in the asymptotic normality of the posterior distribution in Gaussian linear regression models when the number of regressors increases with the sample size. Two kinds of Bernstein-von Mises Theorems are obtained in this framework: nonparametric theorems for the parameter itself, and semiparametric theorems for functionals of the parameter. We apply them to the Gaussian sequence model and to the regression of functions in Sobolev and $C^α$ classes, in which we get the minima…
The prominent Bernstein -- von Mises (BvM) result claims that the posterior distribution after centering by the efficient estimator and standardizing by the square root of the total Fisher information is nearly standard normal. In particular, the prior completely washes out from the asymptotic posterior distribution. This fact is fundamental and justifies the Bayes approach from the frequentist viewpoint. In the nonparametric setup the situation changes dramatically and the impact of prior becomes essential even for the contraction of the posterior; see [vdV2008], [Bo2011], [CaNi2013,CaNi2014]…
We study Empirical Risk Minimizers (ERM) and Regularized Empirical Risk Minimizers (RERM) for regression problems with convex and $L$-Lipschitz loss functions. We consider a setting where $|\cO|$ malicious outliers contaminate the labels. In that case, under a local Bernstein condition, we show that the $L_2$-error rate is bounded by $ r_N + AL |\cO|/N$, where $N$ is the total number of observations, $r_N$ is the $L_2$-error rate in the non-contaminated setting and $A$ is a parameter coming from the local Bernstein condition. When $r_N$ is minimax-rate-optimal in a non-contaminated setting, th…
In a smooth semiparametric estimation problem, the marginal posterior for the parameter of interest is expected to be asymptotically normal and satisfy frequentist criteria of optimality if the model is endowed with a suitable prior. It is shown that, under certain straightforward and interpretable conditions, the assertion of Le Cam's acclaimed, but strictly parametric, Bernstein-von Mises theorem [Univ. California Publ. Statist. 1 (1953) 277-329] holds in the semiparametric situation as well. As a consequence, Bayesian point-estimators achieve efficiency, for example, in the sense of Hájek's…
A constrained multivariate linear model is a multivariate linear model with the columns of its coefficient matrix constrained to lie in a known subspace. This class of models includes those typically used to study growth curves and longitudinal data. Envelope methods have been proposed to improve estimation efficiency in the class of unconstrained multivariate linear models, but have not yet been developed for constrained models that we develop in this article. We first compare the standard envelope estimator based on an unconstrained multivariate model with the standard estimator arising from…
Although the log-likelihood is widely used in model selection, the log-likelihood ratio has had few applications in this area. We develop a log-likelihood ratio based method for selecting regression models by focusing on the set of models deemed plausible by the likelihood ratio test. We show that when the sample size is large and the significance level of the test is small, there is a high probability that the smallest model in the set is the true model; thus, we select this smallest model. The significance level of the test serves as a parameter for this method. We consider three levels of t…
High-dimensional data have recently been analyzed because of data collection technology evolution. Although many methods have been developed to gain sparse recovery in the past two decades, most of these methods require selection of tuning parameters. As a consequence of this feature, results obtained with these methods heavily depend on the tuning. In this paper we study the theoretical properties of sign-constrained generalized linear models with convex loss function, which is one of the sparse regression methods without tuning parameters. Recent studies on this topic have shown that, in the…
We propose a likelihood ratio statistic for forming hypothesis tests and confidence intervals for a nonparametrically estimated univariate regression function, based on the shape restriction of concavity (alternatively, convexity). Dealing with the likelihood ratio statistic requires studying an estimator satisfying a null hypothesis, that is, studying a concave least-squares estimator satisfying a further equality constraint. We study this null hypothesis least-squares estimator (NLSE) here, and use it to study our likelihood ratio statistic. The NLSE is the solution to a convex program, and …
A regression model is proposed for the analysis of an ordinal response variable depending on a set of multiple covariates containing ordinal and potentially other variables. The proportional odds model (McCullagh (1980)) is used for the ordinal response, and constrained maximum likelihood estimation is used to account for the ordinality of covariates. Ordinal predictors are coded by dummy variables. The parameters associated to the categories of the ordinal predictor(s) are constrained, enforcing them to be monotonic (isotonic or antitonic). A decision rule is introduced for classifying the or…
In this paper, we propose a new method for estimation and constructing confidence intervals for low-dimensional components in a high-dimensional model. The proposed estimator, called Constrained Lasso (CLasso) estimator, is obtained by simultaneously solving two estimating equations---one imposing a zero-bias constraint for the low-dimensional parameter and the other forming an $\ell_1$-penalized procedure for the high-dimensional nuisance parameter. By carefully choosing the zero-bias constraint, the resulting estimator of the low dimensional parameter is shown to admit an asymptotically norm…
Maximum approximate Bernstein likelihood estimates of the baseline density function and the regression coefficients in the proportional hazard regression models based on interval-censored event time data are proposed. This results in not only a smooth estimate of the survival function which enjoys faster convergence rate but also improved estimates of the regression coefficients. Simulation shows that the finite sample performance of the proposed method is better than the existing ones. The proposed method is illustrated by real data applications.
Shape-constrained inference has wide applicability in bioassay, medicine, economics, risk assessment, and many other fields. Although there has been a large amount of work on monotone-constrained univariate curve estimation, multivariate shape-constrained problems are much more challenging, and fewer advances have been made in this direction. With a focus on monotone regression with multiple predictors, this current work proposes a projection approach to estimate a multiple monotone regression function. An initial unconstrained estimator -- such as a local polynomial estimator or spline estima…
We study the estimation error of constrained M-estimators, and derive explicit upper bounds on the expected estimation error determined by the Gaussian width of the constraint set. Both of the cases where the true parameter is on the boundary of the constraint set (matched constraint), and where the true parameter is strictly in the constraint set (mismatched constraint) are considered. For both cases, we derive novel universal estimation error bounds for regression in a generalized linear model with the canonical link function. Our error bound for the mismatched constraint case is minimax opt…
The order of smoothness chosen in nonparametric estimation problems is critical. This choice balances the tradeoff between model parsimony and data overfitting. The most common approach used in this context is cross-validation. However, cross-validation is computationally time consuming and often precludes valid post-selection inference without further considerations. With this in mind, borrowing elements from the objective Bayesian variable selection literature, we propose an approach to select the degree of a polynomial basis. Although the method can be extended to most series-based smoother…
Wuhan University（武汉大学）；The Hong Kong University of Science and Technology（香港科技大学）
This paper studies the approximation capacity of ReLU neural networks with norm constraint on the weights. We prove upper and lower bounds on the approximation error of these networks for smooth function classes. The lower bound is derived through the Rademacher complexity of neural networks, which may be of independent interest. We apply these approximation bounds to analyze the convergences of regression using norm constrained neural networks and distribution estimation by GANs. In particular, we obtain convergence rates for over-parameterized neural networks. It is also shown that GANs can …
DNA copy number and mRNA expression are widely used data types in cancer studies, which combined provide more insight than separately. Whereas in existing literature the form of the relationship between these two types of markers is fixed a priori, in this paper we model their association. We employ piecewise linear regression splines (PLRS), which combine good interpretation with sufficient flexibility to identify any plausible type of relationship. The specification of the model leads to estimation and model selection in a constrained, nonstandard setting. We provide methodology for testing …
We consider an equivariant approach imposing data-driven bounds for the variances to avoid singular and spurious solutions in maximum likelihood (ML) estimation of clusterwise linear regression models. We investigate its use in the choice of the number of components and we propose a computational shortcut, which significantly reduces the computational time needed to tune the bounds on the data. In the simulation study and the two real-data applications, we show that the proposed methods guarantee a reliable assessment of the number of components compared to standard unconstrained methods, toge…
Department of Computer Science and Engineering（计算机科学与工程系）；State University of New York at Buffalo（纽约州立大学布法罗分校）
In this paper, we revisit the large-scale constrained linear regression problem and propose faster methods based on some recent developments in sketching and optimization. Our algorithms combine (accelerated) mini-batch SGD with a new method called two-step preconditioning to achieve an approximate solution with a time complexity lower than that of the state-of-the-art techniques for the low precision case. Our idea can also be extended to the high precision case, which gives an alternative implementation to the Iterative Hessian Sketch (IHS) method with significantly improved time complexity.…
We address the problem of how to achieve optimal inference in distributed quantile regression without stringent scaling conditions. This is challenging due to the non-smooth nature of the quantile regression (QR) loss function, which invalidates the use of existing methodology. The difficulties are resolved through a double-smoothing approach that is applied to the local (at each data source) and global objective functions. Despite the reliance on a delicate combination of local and global smoothing parameters, the quantile regression model is fully parametric, thereby facilitating interpretat…
We study the problem of online generalized linear regression in the stochastic setting, where the label is generated from a generalized linear model with possibly unbounded additive noise. We provide a sharp analysis of the classical follow-the-regularized-leader (FTRL) algorithm to cope with the label noise. More specifically, for $σ$-sub-Gaussian label noise, our analysis provides a regret upper bound of $O(σ^2 d \log T) + o(\log T)$, where $d$ is the dimension of the input vector, $T$ is the total number of rounds. We also prove a $Ω(σ^2d\log(T/d))$ lower bound for stochastic online linear …
Hybrid Bernstein Normalizing Flows for Flexible Multivariate Density Regression with Interpretable Marginals
Institute for Applied Research HTWG - University of Applied Sciences（应用研究研究所 HTWG - 高等专业学院）；Chair of Statistics and Campus Institute Data Science (CIDAS) University of Göttingen（统计学教授及校园数据科学研究所 (CIDAS) 雷姆森大学）；Department of Statistics LMU Munich（统计学系 慕尼黑大学）；Munich Center for Machine Learning (MCML)（慕尼黑机器学习中心）
We discuss Bayesian nonparametric procedures for the regression analysis of compositional responses, that is, data supported on a multivariate simplex. The procedures are based on a modified class of multivariate Bernstein polynomials and on the use of dependent stick-breaking processes. A general model and two simplified versions of the general model are discussed. Appealing theoretical properties such as continuity, association structure, support, and consistency of the posterior distribution are established. Additionally, we exploit the use of spike-and-slab priors for choosing the version …
In many applications there is interest in estimating the relation between a predictor and an outcome when the relation is known to be monotone or otherwise constrained due to the physical processes involved. We consider one such application--inferring time-resolved aerosol concentration from a low-cost differential pressure sensor. The objective is to estimate a monotone function and make inference on the scaled first derivative of the function. We proposed Bayesian nonparametric monotone regression which uses a Bernstein polynomial basis to construct the regression function and puts a Dirichl…
In professional tennis, it is often acknowledged that the server has an initial advantage. Indeed, the majority of points are won by the server, making the serve one of the most important elements in this sport. In this paper, we focus on the role of the serve advantage in winning a point as a function of the rally length. We propose a Bayesian isotonic logistic regression model for the probability of winning a point on serve. In particular, we decompose the logit of the probability of winning via a linear combination of B-splines basis functions, with athlete-specific basis function coefficie…
Generalized additive models (GAMs) play an important role in modeling and understanding complex relationships in modern applied statistics. They allow for flexible, data-driven estimation of covariate effects. Yet researchers often have a priori knowledge of certain effects, which might be monotonic or periodic (cyclic) or should fulfill boundary conditions. We propose a unified framework to incorporate these constraints for both univariate and bivariate effect estimates and for varying coefficients. As the framework is based on component-wise boosting methods, variables can be selected intrin…
Many regularization schemes for high-dimensional regression have been put forward. Most require the choice of a tuning parameter, using model selection criteria or cross-validation schemes. We show that a simple non-negative or sign-constrained least squares is a very simple and effective regularization technique for a certain class of high-dimensional regression problems. The sign constraint has to be derived via prior knowledge or an initial estimator but no further tuning or cross-validation is necessary. The success depends on conditions that are easy to check in practice. A sufficient con…
An algorithm is proposed that enables the imposition of shape constraints on regression curves, without requiring the constraints to be written as closed-form expressions, nor assuming the functional form of the loss function. This algorithm is based on Sequential Monte Carlo-Simulated Annealing and only relies on an indicator function that assesses whether or not the constraints are fulfilled, thus allowing the enforcement of various complex constraints by specifying an appropriate indicator function without altering other parts of the algorithm. The algorithm is illustrated by fitting ration…
Functional BART with Shape Priors: A Bayesian Tree Approach to Constrained Functional Regression
The University of Texas Health Science Center at Houston（德克萨斯大学健康科学中心休斯顿分校）；Beijing Technology and Business University（北京工商大学）；Beijing Normal-Hong Kong Baptist University（香港中文大学（深圳））
Determination of Particle-Size Distributions from Light-Scattering Measurement Using Constrained Gaussian Process Regression
Aalto University, Department of Electrical Engineering and Automation (EEA)（阿alto大学电子工程与自动化学院）；Aalto University, Department of Electrical Engineering（阿alto大学电子工程学院）
Shape constrained regression analysis has applications in dose-response modeling, environmental risk assessment, disease screening and many other areas. Incorporating the shape constraints can improve estimation efficiency and avoid implausible results. We propose two novel methods focusing on Bayesian monotone curve and surface estimation using Gaussian process projections. The first projects samples from an unconstrained prior, while the second projects samples from the Gaussian process posterior. Theory is developed on continuity of the projection, posterior consistency and rates of contrac…
The Kalman filter (KF) is one of the most widely used tools for data assimilation and sequential estimation. In this work, we show that the state estimates from the KF in a standard linear dynamical system setting are equivalent to those given by the KF in a transformed system, with infinite process noise (i.e., a "flat prior") and an augmented measurement space. This reformulation -- which we refer to as augmented measurement sensor fusion (SF) -- is conceptually interesting, because the transformed system here is seemingly static (as there is effectively no process model), but we can still c…
We typically construct optimal designs based on a single objective function. To better capture the breadth of an experiment's goals, we could instead construct a multiple objective optimal design based on multiple objective functions. While algorithms have been developed to find multi-objective optimal designs (e.g. efficiency-constrained and maximin optimal designs), it is far less clear how to verify the optimality of a solution obtained from an algorithm. In this paper, we provide theoretical results characterizing optimality for efficiency-constrained and maximin optimal designs on a discr…
Sparse additive modeling is a class of effective methods for performing high-dimensional nonparametric regression. This paper develops a sparse additive model focused on estimation of treatment effect-modification with simultaneous treatment effect-modifier selection. We propose a version of the sparse additive model uniquely constrained to estimate the interaction effects between treatment and pretreatment covariates, while leaving the main effects of the pretreatment covariates unspecified. The proposed regression model can effectively identify treatment effect-modifiers that exhibit possibl…
This paper presents a practical and simple fully nonparametric multivariate smoothing procedure that adapts to the underlying smoothness of the true regression function. Our estimator is easily computed by successive application of existing base smoothers (without the need of selecting an optimal smoothing parameter), such as thin-plate spline or kernel smoothers. The resulting smoother has better out of sample predictive capabilities than the underlying base smoother, or competing structurally constrained models (GAM) for small dimension (3 < d < 8) and moderate sample size (n < 800). Moreove…
We study in detail the two main algorithms which have been considered for fitting constrained marginal models to discrete data, one based on Lagrange multipliers and the other on a regression model. We show that the updates produced by the two methods are identical, but that the Lagrangian method is more efficient in the case of identically distributed observations. We provide a generalization of the regression algorithm for modelling the effect of exogenous individual-level covariates, a context in which the use of the Lagrangian algorithm would be infeasible for even moderate sample sizes. A…
