基于微流控芯片的石英回音壁谐振器介电常数测量
Quartz Whispering-Gallery-Mode Resonator with Microfluidic Chip as Sensor for Permittivity Measurement of Liquids
摘要：
生物溶液的研究需要高测量精度、检测物质浓度低变化的能力以及少量的待测液体。微波复介电常数测量技术的基础上的高品质因数回音壁模式谐振器与微流体芯片允许少量的介电液体进行高精度的研究。基于蓝宝石谐振器的现有技术不提供用于具有低分子量的物质的低浓度检测极限。在这里，我们提出了一种先进的技术的基础上的石英介质谐振器。发现对于水溶液中的葡萄糖获得的检测限对于石英谐振器单元比对于基于MEMS谐振器的测量单元低约一个数量级。该限值约等于或低于人体血液中葡萄糖的浓度。这一事实意味着，该技术可以被用作传感器的生物解决方案在微波范围内的调查。利用研制的传感器在Ka波段成功地对葡萄糖、乳清蛋白和牛血清白蛋白进行了研究。
英文摘要：
Studies of biological solutions require high measurement accuracy, the ability to detect low changes in substance concentration, and small amounts of the liquid under test. A microwave complex permittivity measurement technique based on a high-quality-factor whispering-gallery-mode resonator with a microfluidic chip allows small amounts of dielectric liquids to be investigated with high accuracy. An existing technique based on a sapphire resonator does not provide for a low-concentration detection limit for substances with low molecular weight. Here, we present an advanced technique based on a quartz dielectric resonator. The detection limit obtained for glucose in water solution was found to be about one order of magnitude lower for the quartz resonator cell than for the sapphire-resonator-based measurement cell. The limit is about or lower than the concentration of glucose in human blood. This fact means that the technique can be used as the sensor for investigations of biological solutions in the microwave range. A study of glucose, lactalbumin, and bovine serum albumin was successfully performed in the Ka -band using the developed sensor.
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