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arXiv 2203.16627stat.ME
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将暴露不确定性纳入健康分析的贝叶斯框架及其在空气污染和死产中的应用

A Bayesian framework for incorporating exposure uncertainty into health analyses with application to air pollution and stillbirth

Saskia Comess, Howard H. Chang, Joshua L. Warren

摘要:

环境暴露与不良健康结果之间关系的研究通常依赖于两阶段统计建模方法,在第一阶段对暴露进行建模/预测,并在第二阶段将其用作单独拟合健康结果分析的输入。在估计感兴趣的关联时,这些预测中的不确定性经常被忽略,或者以过于简单的方式被考虑。工作在贝叶斯设置,我们提出了一个灵活的核密度估计(KDE)的方法,充分利用后输出的第一阶段的建模/预测,在第二阶段的接触和健康之间的关联作出准确的推断,获得有效的模型拟合所需的完整的条件分布,详细的连接与现有的方法,并通过模拟比较其性能。我们的KDE方法通常在几个设置和模型比较指标上都有改进的性能。使用竞争的方法,我们调查了新泽西州(2011-2015年)滞后的每日环境细颗粒物水平和死产计数之间的关联,观察到分娩前三天暴露增加的风险增加。新开发的方法可在R包KDExp中使用。

英文摘要:

Studies of the relationships between environmental exposures and adverse health outcomes often rely on a two-stage statistical modeling approach, where exposure is modeled/predicted in the first stage and used as input to a separately fit health outcome analysis in the second stage. Uncertainty in these predictions is frequently ignored, or accounted for in an overly simplistic manner, when estimating the associations of interest. Working in the Bayesian setting, we propose a flexible kernel density estimation (KDE) approach for fully utilizing posterior output from the first stage modeling/prediction to make accurate inference on the association between exposure and health in the second stage, derive the full conditional distributions needed for efficient model fitting, detail its connections with existing approaches, and compare its performance through simulation. Our KDE approach is shown to generally have improved performance across several settings and model comparison metrics. Using competing approaches, we investigate the association between lagged daily ambient fine particulate matter levels and stillbirth counts in New Jersey (2011-2015), observing an increase in risk with elevated exposure three days prior to delivery. The newly developed methods are available in the R package KDExp.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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