圆偏振光散射法估计早期胃癌浸润深度的蒙特卡罗模拟研究
Depth estimation of tumor invasion in early gastric cancer using scattering of circularly polarized light: Monte Carlo Simulation study
摘要：
本文用蒙特卡罗方法研究了圆偏振光散射对早期胃癌肿瘤浸润深度的定量估计。利用人体胃壁及其癌组织的光学参数，计算了在宽光谱范围内伪健康组织和癌组织散射光的强度和圆偏振。在波长600 nm和950 nm处获得具有相反符号的圆偏振的大差异以及大强度。在这两个波长处，可以通过调节检测角度来调制生物组织的采样深度。在双层伪组织中，癌层在健康层上，反之亦然，散射光的圆偏振度显示出依赖于癌层的厚度和深度的系统性变化，这表明在早期胃癌中活体定量估计癌症进展的可行性。
英文摘要：
Quantitative depth estimation of tumor invasion in early gastric cancer by scattering of circularly polarized light is computationally investigated using the Monte Carlo method. Using the optical parameters of the human stomach wall and its carcinoma, the intensity and circular polarization of light scattered from pseudo-healthy and cancerous tissues were calculated over a wide spectral range. Large differences in the circular polarization with opposite signs, together with the large intensity, are obtained at wavelengths 600 nm and 950 nm. At these two wavelengths, the sampling depth of the biological tissues can be modulated by tuning the detection angle. In bi-layered pseudo-tissues with a cancerous layer on a healthy layer and vice versa, the degree of circular polarization of scattered light shows systematic changes depending on the thickness and depth of the cancerous layer, which indicates the feasibility of in vivo quantitative estimation of cancer progression in early gastric cancer.
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