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arXiv 2203.11461stat.MEstat.ML
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一种面向网络结构多重检验的局部自适应算法

A Locally Adaptive Algorithm for Multiple Testing with Network Structure

Ziyi Liang, T. Tony Cai, Wenguang Sun, Yin Xia

AI总结:

本文提出局部自适应结构学习算法LASLA,通过p值加权整合网络等复杂辅助信息,在渐近控制FDR的同时提升多重检验功效。

摘要:

在主数据之外纳入辅助信息可以显著提高同时推断的准确性。然而,现有的多重检验方法在有效利用复杂边信息方面面临挑战,尤其是当边信息在维度或结构上与主数据不同时,例如网络边信息。本文提出了一种局部自适应结构学习算法(LASLA),这是一个灵活的框架,旨在将广泛的辅助信息整合到推断过程中。尽管LASLA的提出直接源于网络结构数据带来的挑战,但它在其他类型的边信息(如空间位置和多个辅助序列)上也表现出很高的有效性。LASLA采用p值加权方法,利用结构信息推导出数据驱动的权重,以区分不同假设的重要性。我们的理论分析表明,LASLA在独立或弱相关的p值下渐近控制错误发现率(FDR),并且在辅助数据提供有价值边信息的场景中能够获得更高的检验功效。我们通过模拟研究评估了LASLA的数值性能,并通过两个实际应用进一步展示了其有效性。

英文摘要:

Incorporating auxiliary information alongside primary data can significantly enhance the accuracy of simultaneous inference. However, existing multiple testing methods face challenges in efficiently incorporating complex side information, especially when it differs in dimension or structure from the primary data, such as network side information. This paper introduces a locally adaptive structure learning algorithm (LASLA), a flexible framework designed to integrate a broad range of auxiliary information into the inference process. Although LASLA is specifically motivated by the challenges posed by network-structured data, it also proves highly effective with other types of side information, such as spatial locations and multiple auxiliary sequences. LASLA employs a $p$-value weighting approach, leveraging structural insights to derive data-driven weights that prioritize the importance of different hypotheses. Our theoretical analysis demonstrates that LASLA asymptotically controls the false discovery rate (FDR) under independent or weakly dependent $p$-values, and achieves enhanced power in scenarios where the auxiliary data provides valuable side information. Simulation studies are conducted to evaluate LASLA's numerical performance, and its efficacy is further illustrated through two real-world applications.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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