高度可扩展、可穿戴的表面增强拉曼光谱
Highly scalable, wearable surface-enhanced Raman spectroscopy
摘要：
在过去的二十年里，可穿戴传感器技术取得了巨大的发展，主要表现为柔性、可拉伸的皮肤上电子传感器，这些传感器提供了关于穿戴者健康状况和周围环境的丰富信息。该领域最近的一个突破是基于表面增强拉曼光谱（SERS）的可穿戴化学传感器的开发，该传感器可以普遍，灵敏和非侵入性地检测分子指纹。然而，虽然它们的感测特性是优异的，但是这些传感器由于其繁琐的制造工艺和有限的多功能感测能力而不能扩展到小规模人类健康监测之外的广泛使用。在这里，我们展示了一种高度可扩展的，可穿戴的SERS传感器，该传感器基于易于制造，低成本，可折叠，灵活，可拉伸，粘合和生物可集成的金纳米网。它可以制造成任何形状，并佩戴在几乎任何表面上，用于从低浓度到高浓度（10 nM - 1 mM）的各种分析物的无标记、大规模、原位传感。为了展示可穿戴SERS传感器的实用性，我们测试了传感器用于检测汗液生物标志物，滥用药物和微塑料。这种可穿戴SERS传感器代表了可穿戴传感技术的普遍性和实用性的重要一步。
英文摘要：
The last two decades have witnessed a dramatic growth of wearable sensor technology, mainly represented by flexible, stretchable, on-skin electronic sensors that provide rich information of the wearer's health conditions and surroundings. A recent breakthrough in the field is the development of wearable chemical sensors based on surface-enhanced Raman spectroscopy (SERS) that can detect molecular fingerprints universally, sensitively, and noninvasively. However, while their sensing properties are excellent, these sensors are not scalable for widespread use beyond small-scale human health monitoring due to their cumbersome fabrication process and limited multifunctional sensing capabilities. Here we demonstrate a highly scalable, wearable SERS sensor based on an easy-to-fabricate, low-cost, ultrathin, flexible, stretchable, adhesive, and bio-integratable gold nanomesh. It can be fabricated in any shape and worn on virtually any surface for label-free, large-scale, in-situ sensing of diverse analytes from low to high concentrations (10 nM - 1 mM). To show the practical utility of the wearable SERS sensor, we test the sensor for the detection of sweat biomarkers, drugs of abuse, and microplastics. This wearable SERS sensor represents a significant step toward the generalizability and practicality of wearable sensing technology.
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