根据与脑内电刺激同时记录的EEG和sEEG进行人体体内电导率估计的性能评价
Evaluation of Performance for Human In-Vivo Conductivity Estimation from EEG and sEEG Recorded in Simultaneous with Intracerebral Electrical Stimulation
摘要：
准确的头部模型电导率值是实现经颅电刺激（TES）的精确脑电（EEG）源定位和靶向的重要因素。不幸的是，文献报道了人头部不同组织的电导率值不同。本研究首先分析了关于电源和测量的定位的不同配置的体内电导率估计的性能。然后，它提出了三个癫痫患者使用头皮EEG和脑内立体定向EEG（sEEG）与脑内电刺激同时采集的电导率估计。电导率的估计是基于人体头部的有限元模型，该模型具有均匀和各向同性电导率的五个组织隔室。本研究的结果表明，当考虑不同的刺激位置、不同的测量位置或不同的测量模态（sEEG或EEG）时，体内电导率估计可能导致同一患者的不同估计电导率。这项工作提供了重要的指导方针，在体内电导率估计和解释的变异性之间的电导率值已在以前的研究报告。
英文摘要：
Assigning accurate conductivity values in human head models is an essential factor for performing precise electroencephalographic (EEG) source localization and targeting of transcranial electrical stimulation (TES). Unfortunately, the literature reports diverging conductivity values of the different tissues in the human head. The current study analyzes first the performance of in-vivo conductivity estimation for different configurations concerning the localization of the electrical source and measurement. Then, it presents conductivity estimates for three epileptic patients using scalp EEG and intracerebral stereotactic EEG (sEEG) acquired in simultaneous with intracerebral electrical stimulation. The estimates of the conductivities were based on finite-element models of the human head with five tissue compartments of homogeneous and isotropic conductivities. The results of this study show that in-vivo conductivity estimation can lead to different estimated conductivities for the same patient when considering different stimulation positions, different measurement positions or different measurement modalities (sEEG or EEG). This work provides important guidelines to in-vivo conductivity estimation and explains the variability among the conductivity values which have been reported in previous studies.
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