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arXiv 2202.11007math.AP
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具有广义Logistic源的Cahn-Hilliard-Keller-Segel模型

On a Cahn-Hilliard-Keller-Segel model with generalized logistic source describing tumor growth

Elisabetta Rocca, Giulio Schimperna, Andrea Signori

摘要:

我们提出了一种新型的扩散界面模型,描述了在化学物质(例如,营养物或药物)。该过程通过使用变量$φ$和$σ$来描述,变量$φ$是表示肿瘤细胞的局部比例的顺序参数,变量$σ$表示化学物质的浓度。假设序参量$φ$满足具有质量源和对数势的Flory-Huggins型Cahn-Hilliard方程的适当形式(或其推广形式)。化学浓度$σ$满足反应扩散方程,其中交叉扩散项具有与著名的Keller-Segel模型中相同的表达式。在这方面,我们提出的模型代表了一个新的耦合之间的Cahn-Hilliard方程和一个子系统的Keller-Segel模型。我们认为,与其他模型相比,这种选择在捕获肿瘤生长动力学(化学诱导的肿瘤演变和肿瘤细胞消耗营养/药物)中可能发生的趋化作用方面更有效。注意,为了防止$σ$的有限时间爆破,我们假设化学源项为逻辑类型。我们的主要数学结果致力于证明弱解的存在性在一个相当一般的设置,涵盖了二维和三维的情况。在更严格的假设下的系数和数据,并在某些情况下的空间维度,我们证明了各种规律性的结果。最后,在适当的类光滑的解决方案,我们证明了唯一性和连续依赖于初始数据在一些重要的情况下。

英文摘要:

We propose a new type of diffuse interface model describing the evolution of a tumor mass under the effects of a chemical substance (e.g., a nutrient or a drug). The process is described by utilizing the variables $φ$, an order parameter representing the local proportion of tumor cells, and $σ$, representing the concentration of the chemical. The order parameter $φ$ is assumed to satisfy a suitable form of the Cahn-Hilliard equation with mass source and logarithmic potential of Flory-Huggins type (or generalizations of it). The chemical concentration $σ$ satisfies a reaction-diffusion equation where the cross-diffusion term has the same expression as in the celebrated Keller-Segel model. In this respect, the model we propose represents a new coupling between the Cahn-Hilliard equation and a subsystem of the Keller-Segel model. We believe that, compared to other models, this choice is more effective in capturing the chemotactic effects that may occur in tumor growth dynamics (chemically induced tumor evolution and consumption of nutrient/drug by tumor cells). Note that, in order to prevent finite time blowup of $σ$, we assume a chemical source term of logistic type. Our main mathematical result is devoted to proving existence of weak solutions in a rather general setting that covers both the two- and three- dimensional cases. Under more restrictive assumptions on coefficients and data, and in some cases on the spatial dimension, we prove various regularity results. Finally, in a proper class of smooth solutions we show uniqueness and continuous dependence on the initial data in a number of significant cases.

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