通过引导线索控制基于蛋白质的斑图形成
Control of protein-based pattern formation via guiding cues
摘要：
蛋白质控制活细胞中的许多重要功能，如细胞生长和细胞分裂。这些功能的可靠协调需要细胞内蛋白质的空间和时间组织，其编码有关细胞几何形状和细胞周期阶段的信息。这种蛋白质模式产生于蛋白质转运和反应动力学，并且它们可以通过细胞内的各种指导线索来控制。在这里，我们回顾蛋白质模式是如何引导细胞的大小和形状，由其他蛋白质模式，作为模板，并通过细胞的机械性能。结合近年来在各种生物模式生物中的观察，阐明了引导斑图形成的基本机制。我们认为，理解细胞中蛋白质模式的受控形成将是理解生命系统中信息处理的重要组成部分。
英文摘要：
Proteins control many vital functions in living cells, such as cell growth and cell division. Reliable coordination of these functions requires the spatial and temporal organizaton of proteins inside cells, which encodes information about the cell's geometry and the cell-cycle stage. Such protein patterns arise from protein transport and reaction kinetics, and they can be controlled by various guiding cues within the cell. Here, we review how protein patterns are guided by cell size and shape, by other protein patterns that act as templates, and by the mechanical properties of the cell. The basic mechanisms of guided pattern formation are elucidated with reference to recent observations in various biological model organisms. We posit that understanding the controlled formation of protein patterns in cells will be an essential part of understanding information processing in living systems.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
