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arXiv 2202.07191cs.CVcs.LG
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基于非监督解剖特征提取的精子头部形态分类

Improving Human Sperm Head Morphology Classification with Unsupervised Anatomical Feature Distillation

University of Notre Dame(圣母大学);First Affiliated Hospital of Anhui Medical University(安徽医科大学第一附属医院)

Yejia Zhang, Jingjing Zhang, Xiaomin Zha, Yiru Zhou, Yunxia Cao, Danny Z. Chen

摘要:

随着男性不育症的日益增多,精子头部形态学分类对于准确及时的临床诊断至关重要。最近的深度学习(DL)形态学分析方法实现了有希望的基准测试结果,但由于依赖于有限且可能有噪声的类标签,因此性能和鲁棒性有待提高。为了解决这个问题,我们引入了一个新的DL训练框架,该框架利用人类精子显微镜作物的解剖学和图像先验来提取有用的特征,而无需额外的标记成本。我们的核心思想是通过可靠生成的伪掩模和无监督的空间预测任务来提取精子头部信息。然后利用来自该提取步骤的预测前景掩模来在调整阶段中正则化和减少图像和标签噪声。我们在两个公共精子数据集上评估了我们的新方法,并实现了最先进的性能(例如65.9%的SCIAN准确率和96.5%的HuSHeM准确率)。

英文摘要:

With rising male infertility, sperm head morphology classification becomes critical for accurate and timely clinical diagnosis. Recent deep learning (DL) morphology analysis methods achieve promising benchmark results, but leave performance and robustness on the table by relying on limited and possibly noisy class labels. To address this, we introduce a new DL training framework that leverages anatomical and image priors from human sperm microscopy crops to extract useful features without additional labeling cost. Our core idea is to distill sperm head information with reliably-generated pseudo-masks and unsupervised spatial prediction tasks. The predicted foreground masks from this distillation step are then leveraged to regularize and reduce image and label noise in the tuning stage. We evaluate our new approach on two public sperm datasets and achieve state-of-the-art performances (e.g. 65.9% SCIAN accuracy and 96.5% HuSHeM accuracy).

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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